During the period of the Republic of China, the uneven distribution of resources in medical education were very prominent, and the government put forward the university area system reform in order to change the phenomenon. Although the aim of the reform was not to adjust the distribution of medical education, it had the effect of regulation objectively. On the other hand, the government adopted a series of measures to donate money, so as to regulate the distribution of medical school. But for a variety of reasons, the regulation of distribution in medical school was not successful, uneven distribution phenomenon still existed. The analyses of this regulation had certain enlightenment function to the distribution of current medical education.