Man is a meaningful existence, and meaning care is a basic need of human being. Because of the lack of meaning care to medical students, traditional medical humanistic education has impeded the improvement and development of medical students＇ humanistic quality. Nowadays, emphasizing and strengthening the meaning care to medical students is not only determined by the nature of the person＇s behavior, but also the necessities to innovative forms of medical humanistic education and cultivate medical humanistic quality of medical students in the practice of medical humanistic education. To establish the new educational idea, set up the new educational goal, integrate the educational resources, focus on the transformation of knowing－thinking－doing, implement and improve the multiple interactive ways of education, all are the important paths to construct practice mechanism of meaning care on medical humanistic education.