Base on 843 medicine and humanities research articles selected from CNKI core periodical database, this study performed co-occurrence and cluster analyses on the authors, institutions and keywords by the information visualization techniques and tools (CiteSpace Ⅲ). Mapping knowledge domains of the vanguard of the medicine and humanities field were drawn. These results reflect the important literature and important figures in the fields of medicine and humanities and show the relationship and evolution of the medicine and humanities knowledge structure.