Objective:To explore the quality of life (QOL) and its influential factors of rural type 2 diabetes mellitus (T2DM) patients. Methods:A total of 291 T2DM patients were investigated with a self-designed questionnaire and the diabetes specific quality of life (DSQL) scale. Univariate analysis and multivariate analysis were performed to explore the influential factors. Results:The QOL of T2DM patients was poor,and the total score of DSQL was 54.99±11.88;the QOL of female,patients with low culture degree,long time sitting,lack of exercise,other chronic diseases,and mental burdens was lower. Conclusion:Focusing on the female and low culture degree patients,strengthening the prevention of chronic diseases,valuing the psychological health and encouraging moderate exercise had great significance to improve the QOL of T2DM patients.