OBJECTIVE The purpose of this study was to evaluate the application of contrast-enhanced ultrasound and MRI patterns in the diagnosis of soft-tissue masses. MATERIALS AND METHODS A retrospective study was performed with 41 cases from May 2018 to February 2020 which had clinical records of soft-tissue masses and imaging data. Logistic regression analysis was used to determine the relationships between diagnostic properties of the masses (benign or malignant) and patients’ age, gender, lesion layer, location or size. Imaging results were described as four predefined contrast enhancement (CE) pattern (P1, P2, P3, P4), and the correlations between CE patterns and masses properties were assessed by contingency table analysis. RESULTS All 41 soft tissue masses were obtained by puncture or surgery, which examined by contrast enhanced ultrasound （CEUS）and contrast-enhanced Magnetic Resonance Imaging (MRI) before the surgery or puncture. Logistic regression analysis showed that there was no significant correlation between tumor properties (benign or malignant) and patients’ age, gender, the size of the mass, location or lesion layer. P1 and P2 pattens of two examinations were both benign lessions. Both CEUS and MRI enhancement of soft tissue masses showed that P3 enhancement pattern was correlated with malignant tumor （P≤0.001). The sensitivity, specificity, positive predictive value and negative predictive value of CEUS were 89.7% 66.7% 86.7%, 72.7% while MR enhanced sensitivity, specificity, positive predictive value, negative predictive value were 96.6% 58.3% 84.8% 87.5%). The two kinds examinations had no statistical significance of diagnostic efficiency. CONCLUSIONS Both contrast-enhanced ultrasound and MRI could provide information for the diagnosis of an unknown soft-tissue mass.