Objective To analyze the risk factors related to APOE gene polymorphism and advanced glycation end products in elderly patients with coronary heart disease.Methods The distribution of APOE gene polymorphism in 46 elderly patients with coronary heart disease and 44 non-coronary heart disease patients (control group) was observed and the plasma levels of CML and sRAGE were determined by ELISA.Results The allele frequency of ApoE ε4 in coronary heart disease group was significantly higher than that of the control group (P < 0.05), and the level of plasma CML and sRAGE in coronary heart disease group was higher than that of the control group, with no statistically significant difference.The plasma CML and sRAGE levels of APOE ε4 carriers in the coronary heart disease group were not significantly different from those in the control group.The risk factors of coronary heart disease in elderly patients with APOE ε4 carriers were 3.511 times that of non-carriers (P < 0.05), but CML and sRAGE levels were not significantly associated with an increased risk of coronary heart disease.Conclusion With age, APOE ε4 allele remained an independent risk factor for coronary heart disease in elderly patients, and there was no significant correlation between advanced glycation end products level and coronary heart disease in elderly patients.