Abstract:Control of cholesterol levels can reduces the incidence of atherosclerotic cardiovascular disease(ASCVD). Low-density lipoprotein cholesrerol has been an independent risk factor of ASCVD. Statins, Cholesrerol absorption inhibitor, Bile acid sequestrant have been proved effectively for reduction of Low-density lipoprotein cholesterol. New type therapeutic drugs Proprotein convertase subtilisin/kexin type 9 inhibitors, microsomal TG transfer protein inhibitor, antisense oligonucleotide inhibitors,peroxisome proliferator-activated receptor-α have also achieved clinical benefit in recent clinical trials. In this article, we will review the efficacy and safty of Cholesterol-lowering drugs, so that we can find out the most effective plan of cholesterol management.