Objective: The aim of this study is to compare the perioperative curative effect of total arterial and single internal-thoracicartery coronary artery bypass grafts. Methods: 100 patients who received coronary artery bypass graft(CABG) from January 2018 to June 2019 in The First Affiliated Hospital of Nanjing Medical University were collected for retrospective analysis. The total arterialized group was 50 patients who received total arterial bypass, the left 50 patients received left internal mammary artery（LIMA）and great saphenous vein(SVG) bypass in the conventional group. Off-pump CABG was used in all cases. We compared hospital stays, perioperative indicators, complication rate, and so on in two groups as the clinical data. Results: The operation time in total arterialized group is longer than in the conventional group(5.08±0.87h vs 4.28±1.08h，P<0.05). There was no difference in hospital stay, mechanical ventilation time and drainage, troponin T, creatine kinase-MB(CK-MB) 24 hours after operation(P>0.05). Complication rate like wound infection, atrial fibrillation, and so on is similar between the two groups. No statistical difference can be found in blood transfusion percentage and in the plasma, red blood cells, platelet, cryo transfusion percentage(P>0.05). Conclusion: Total arterial has an almost perioperative curative effect with the conventional single internal-thoracicartery grafts, though the operation time is longer. There’s no increase in perioperative risk.