乳腺癌前哨淋巴结转移患者中非前哨淋巴结状态的影响因素分析
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宜兴市人民医院

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] 江苏省卫生计生委 江苏省青年医学重点人才培养项目(QNRC2016-208) 无锡市卫生健康委妇幼健康科研项目 (FYKY201907)1通讯作者(Corresponding author),E-mail:staff984@yxph.com


Analysis of risk factors of non-sentinel lymph node status in patients with sentinel lymph node metastasis of breast cancer
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    摘要:

    目的: 乳腺癌前哨淋巴结(SLN)转移患者中非前哨淋巴结(NSLN)状态的影响因素分析。 方法: 选取2016年1月至2020年6月期间于我院行前哨淋巴结活检术(SLNB)的乳腺癌患者,均为女性患者。对单因素分析中具有统计学意义的NSLN转移危险因素将采用Logistic回归模型进行多因素分析。 结果: 研究共纳入符合要求的患者136例,其中NSLN阴性62例,NSLN阳性74例,比较资料发现原发肿瘤大小、脉管癌栓、SLN阳性数目及SLN阳性比例是影响乳腺癌NSLN转移的危险因素(P<0.05)。将上述资料纳入Logistic回归分析,结果提示脉管癌栓、SLN阳性比例是乳腺癌患者NSLN发生转移的独立危险因素(P均<0.05)。 结论: 脉管癌栓、SLN阳性比例是乳腺癌患者NSLN发生转移的独立危险因素,当乳腺癌患者存在脉管癌栓、SLN阳性比例≥0.5时更容易发生NSLN转移。

    Abstract:

    Objective Analysis of risk factors for non-sentinel lymph node (NSLN) status of non-sentinel lymph nodes in patients with sentinel lymph node (SLN) metastasis in breast cancer. Methods The patients with breast cancer who underwent sentinel lymph node biopsy (SLNB) in our hospital from January 2016 to June 2020 were all female patients. Logistic regression model was used to analyze the risk factors of NSLN metastasis in univariate analysis. Results A total of 136 patients were included in the study, including 62 cases with NSLN negative and 74 cases with NSLN positive. Comparative data showed that primary tumor size, vascular tumor thrombus, SLN positive number and SLN positive ratio were the risk factors affecting the metastasis of breast cancer (P<0.05). Logistic regression analysis showed that vascular tumor thrombus and SLN positive rate were independent risk factors for metastasis of NSLN in breast cancer patients (P < 0.05). Conclusion The positive rates of SLN and vascular tumor thrombus were independent risk factors for NSLN metastasis in breast cancer patients. NSLN metastasis was more likely to occur in breast cancer patients with vascular tumor thrombus and SLN positive ratio ≥0.5.

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  • 收稿日期:2020-12-12
  • 最后修改日期:2021-03-22
  • 录用日期:2021-06-02
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