帕金森病视幻觉发生机制研究进展
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南京医科大学附属脑科医院老年神经科

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江苏省重点研发计划专项资金,国家重点研发计划,江苏省“333高层次人才培养工程”专项基金


Research progress on pathogenesis of visual hallucination in Parkinson"s disease
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Department of Geriatric neurology, Brain Hospital of Nanjing Medical University

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Special Funds of the Jiangsu Provincial Key Research and Development Projects,Key Research and Development Project of the Ministry of Science and Technology,Special Funds of the Jiangsu Provincial 333 High-level Talent Cultivation Projects

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    摘要:

    视幻觉是帕金森病中最常见的精神障碍,与帕金森病患者的生活质量受损密切相关,并对患者预后产生不利影响,但其发病机制尚未明确。研究者发现视幻觉与脑部结构、视觉通路和注意网络及神经递质密切相关,在流行病学、组织病理学、临床特征等方面存在强有力的证据支持。本文结合国内外多学科研究成果,对帕金森病伴发视幻觉的发病机制进行探讨。

    Abstract:

    Visual hallucination (VH) is the most common psychiatric symptom in Parkinson's disease (PD), which is closely related to the impaired quality of life and adversely affects the prognosis of patients. However, its pathogenesis is not yet clear. VH has been found to have relationship with disturbance in brain structures, visual pathways and attention networks, as well as neurotransmitters and there is strong evidence to support these findings in epidemiology, histopathology, clinical features and so on. Based on the results of multi-disciplinary research at home and abroad, this paper is to discusses the pathogenesis of visual hallucination in PD.

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  • 收稿日期:2020-12-23
  • 最后修改日期:2021-04-21
  • 录用日期:2021-09-28
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