金纳米颗粒-微气泡复合材料及其体外成像和光热性能研究
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南京医科大学生物医学工程系

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国家自然科学基金 81701833;国家重点研发计划2019YFA0210104


Controlled assembly of Gold nanoparticles on microbubbles for ultrasound imaging and photothermal therapy in vitro.
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Department of Biomedical Engineering,NMU

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    摘要:

    目的:构建两种结构的金纳米颗粒-微气泡复合材料,即能作为超声成像造影剂,又可以利用金纳米颗粒的表面等离子体共振效应进行光热转换。方法:一种是将金纳米颗粒包裹在微气泡气体内核中的包金微气泡(AuMBs),另一种是通过共价键结合的方式将金纳米颗粒装载到微气泡表面的载金微气泡(PEI-AuMBs),对这类金纳米颗粒-微气泡复合材料进行了理化性质的表征,通过体外超声成像评估了其超声造影能力,通过体外光热实验评估了其光热转换能力。结果:两种复合结构的微气泡均显示出比空白微气泡(MBs)更好的超声造影能力,其中PEI-AuMBs在超声造影增强的持续时间上有更好的表现;两种复合结构的微气泡也显示出比单纯金纳米颗粒更优异的光热转换能力, AuMBs有更好的光热治疗潜力。结论:金纳米-微气泡复合材料是具有潜力的诊疗一体化载体系统。

    Abstract:

    Objective: Two gold nanoparticle-microbubble composites with different structures were constructed, which can be used both as ultrasound imaging contrast agents and for photothermal conversion using the surface plasmonic excitonic effect of gold nanoparticles. Methods: One is gold encapsulated microbubbles (AuMBs) with gold nanoparticles encapsulated in a microbubble gas core, and the other is gold loaded microbubbles (PEI-AuMBs) with gold nanoparticles loaded onto the microbubble surface by covalent bonding. These gold nanoparticle-microbubble composites were characterized for their physicochemical properties, and their ultrasound contrast capabilities were evaluated by in vitro ultrasound imaging. Their photothermal conversion ability was evaluated by in vitro photothermal experiments. Results: Both composite microbubbles showed better ultrasonography ability than blank microbubbles (MBs), among which PEI-AuMBs showed better performance in the duration of ultrasonography enhancement; both composite microbubbles also showed superior photothermal conversion ability than gold nanoparticles alone, and AuMBs had better photothermal therapeutic potential. Conclusion: All these results demonstrates that gold nano-microbubble composites are promising carrier systems for therapeutic integration.

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  • 收稿日期:2021-03-05
  • 最后修改日期:2021-04-11
  • 录用日期:2021-06-21
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