Objectives: The clinical manifestations of patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis in East China and factors associated with prognosis were analyzed. Methods: A retrospective study of 106 patients (58 females; 48 males) with anti-NMDAR encephalitis in East China was carried out from June 2015 to February 2020. Clinical features and factors influencing outcomes were reviewed. Results: Behavioral changes were observed in 74.5% (79/106) of patients, and comprised the initial symptoms in 61.3% (65/106). Seizures were observed in 67% (71/106) of patients, and served as initial symptoms in 31.1% (33/106). A total of 54.9% (39/71) of seizures were focal seizures. The patients with high cerebrospinal fluid (CSF) antibody titers experienced more clinical symptoms than those with low CSF antibody titers (female mean: 4.06±0.98 vs 1.88± 0.86, P=0.000; respectively, male mean: 2.29±1.0 vs 1.50 ±0.79, P=0.006). One hundred and fourteen electroencephalography(EEG) or video EEG recordings were obtained from 92 patients. EEG background activity (BA) was significantly aggravated at 12 days. A total of 72.5% (74/102) of patients showed normal magnetic resonance imagings (MRIs). Brain lesions were observed in 27.45% of patients (28/102).During the peak stage of the disease, focal high blood flow with normal MRIs were observed from 56.52% (13/23) arterial spin labeling (ASL) of anti-NMDAR encephalitis patients. Focal high blood flow with brain lesions were observed in 39.13% (9/23) ASL of patients. The Binary logistic regression analyses revealed the factors associated with poor outcomes included consciousness disturbance, EEG BA, number of symptoms and CSF antibody titer. Conclusion: EEG BA and number of symptoms were associated with CSF antibody titers. Consciousness disturbances, EEG BA, number of symptoms and increasing CSF antibody titers served as predictors of poor outcomes.