Glaucoma is a common neurodegenerative disease with complex pathogenesis, which seriously threatens human eye health.The establishment of glaucoma animal model provides a research basis for the occurrence, development and intervention of glaucoma.Based on the brief introduction of glaucoma, this paper describes the current construction methods of animal models of glaucoma from the two perspectives of spontaneous and artificially induced glaucoma animal models.An animal model of glaucoma can only simulate a certain type of glaucoma or the pathological changes of one aspect of glaucoma.Therefore, we should choose a reasonable animal model according to different experimental needs.With the development of biotechnology and basic scientific research, as well as the in-depth understanding of the pathogenesis of glaucoma, it is expected to further improve the existing models or develop new induction mechanisms to overcome the current limitations, so that we can better understand and intervene the occurrence and development of glaucoma in the future.