Objective:The incidence of intraoperative and postoperative complications of great saphenous vein in the group with endoscopic vein harvesting (EVH) and in the group with routine open vein harvesting (OVH) were compared.To investigate the feasibility and safety of endoscopic great saphenous vein collection in coronary artery bypass grafting (CABG). Methods:A retrospective analysis was performed on 80 patients with off-pump coronary artery bypass grafting (CABG) in the single treatment group from July 2020 to July 2021. The patients were divided into the EVH group (n = 40) and the OVH group (n = 40) according to the method of great saphanic vein acquisition.Preoperative, intraoperative and postoperative indexes were observed. Results:Compared with the OVH group, the operative time (P=0.370)、total number of bypass grafts (P=0.819)、 repair times of great saphenous vein (P=0.474), postoperative mechanical ventilation time (P=0.080)、 postoperative hospital stay (P=0.994)、second thoracotomy hemostasis rate (P=1.000)、 perioperative mortality (P=1.000) 、total hospitalization costs（P=0.078）and the incidence of adverse events (P=1.000) showed no significant statistical differences.Compared with the OVH group, the length of lower extremity incision in EVH group (P=< 0.0001) was significantly shorter, and postoperative lower extremity incision pain (P=< 0.0001), numbness (P=0.025) and fat liquefaction (P=0.005) were significantly decreased with statistical difference. Conclusion: Endoscope-assisted great saphenous vein acquisition can significantly reduce the lower extremity complications after CABG in patients with coronary heart disease, and greatly reduce the incidence of lower extremity pain,numbness and poor wound healing, which provides convenience for patients to move to the ground as soon as possible and is conducive to the rehabilitation of patients.