南京医科大学附属苏州医院肝胆外科 江苏 苏州 215002
Affiliated Suzhou Hospital of Nanjing Medical University
Suzhou Key Medical Discipline (SZXK201808)
肝脏肿瘤早期诊断率低,大部分患者初诊即失去手术机会。剩余肝脏体积(future liver remnant, FLR)不足是无法手术的主要原因,这已成为制约肝脏外科发展的瓶颈。联合肝脏离断和门静脉结扎二步肝切除术(associating liver partition and portal vein ligation for staged hepatectomy, ALPPS)能够促进剩余肝脏快速增生,进而接受手术切除,显著改善了无法手术患者的预后。但这项技术开展之初,因其安全性问题争议较大,现已得到明显改善。本文将通过总结ALPPS相关文献来阐述其临床应用方面的进展。
The early diagnostic rate of liver cancer is low. Most patients lose the opportunity for surgical resection when they are first diagnosed. It is not eligible for patients to achieve operations mainly due to deficient future liver remnant (FLR) which obstacles the development of liver surgery. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) enables patients undergo radical excision by rapid liver hypertrophy, which significantly improves the prognosis of patients. Now ALPPS has substantially gained the improvement, which was remarkably controversial for its safety issue in the early stage of practice. This review will elaborate the progress of clinical applications by synthesizing the articles concerning ALPPS.