Objective：We aimed to discuss the clinical features of cerebral hemorrhage in patients with maintenance hemodialysis and the related factors affecting prognosis. Methods： We collected clinical information of patients with cerebral hemorrhage and maintenance hemodialysis in our hospital from January 2016 to December 2020. According to the improved Rankin scale score on the ninetieth day after cerebral hemorrhage, all rolled patients were divided into the good (0-2 points) or poor (3-6 points) outcome group. Clinical information were collected such as gender, age, dialysis age, imaging examination, hemoglobin, serum calcium, albumin, and blood purification. We analyzed the prognosis and explored the risk factors of poor outcome. Results：Eighty-five patients were included in this study. Fifty patients were studied as good outcome group, while 35 patients as the control group. Our results showed that hemoglobin, GCS, hematoma, ventricular hematoma, and serum calcium were associated with poor outcome. Through logistic analysis, GSC, hematoma, and serum calcium were identified as independent risk factors. Conclusion：Low GCS score, huge hematoma, and abnormal serum calcium were associated with poor prognosis. We should pay attention to reduce complications and improve prognosis.