Department of Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University
The National Science Fund for Distinguished Young Scholars.No. 81902453
摘要：目的: 探讨肺浸润性粘液腺癌（invasive mucinous adenocarcinoma ，IMA）的临床病理特点及其预后相关因素。方法：回顾性分析2015年1月至2019年12月期间在南京医科大学第一附属医院行根治性手术治疗且术后病理明确诊断为IMA的106例患者，分析其临床病理特点，并利用统计学软件进行生存分析。结果：14例患者术前CT影像上表现为肺炎型。所有患者均接受根治性手术治疗，50例患者接受了术后辅助治疗。单因素生存分析显示，肺炎型表现、T分期与N分期及是否行辅助治疗是影响IMA患者术后总体生存率的因素（P<0.05）。此外，肺炎型表现、T分期、N分期、手术方式及是否行辅助治疗等因素与患者术后无病生存率相关（P<0.05）。Cox风险评估模型多因素生存分析显示，肺炎型表现及淋巴结转移是影响IMA患者术后总体生存率和无病生存率的独立危险因素（P<0.05）。结论：肺炎型表现以及淋巴结转移与肺IMA的不良预后相关。
Abstract： Objective: To investigate the clinicopathological features and prognostic factors of invasive mucinous adenocarcinoma of the lung(IMA) . Methods: From January 2015 to December 2019, 106 patients were identified as having IMA accepted radical resection and enrolled in the retrospective study. Their clinicopathological features were analysed and we conducted a survival analysis with statistical software. Results：14 patients showed pneumonia on preoperative CT images. All patients received radical surgery, and 50 patients received postoperative adjuvant therapy. Univariate survival analysis showed that pneumonia type, T stage and N stage and whether adjuvant treatment were the factors affecting the overall survival rate of IMA patients (P < 0.05). In addition, the expression of pneumonia, T stage, N stage, operation method and whether adjuvant treatment were related to the disease-free survival rate (P < 0.05). Multivariate survival analysis of Cox risk assessment model showed that pneumonia and lymph node metastasis were independent risk factors affecting the overall survival rate and disease-free survival rate of IMA patients (P < 0.05). Conclusion: The manifestation of pneumonia and lymph node metastasis are associated with the poor prognosis of IMA.