胃癌的早期诊治对患者的预后至关重要,研究胃癌前病变发生机制有望实现对胃癌的早期防治。解痉多肽表达化生(Spasmolytic polypeptide expressing metaplasia, SPEM)是重要的胃癌前病变,与胃癌的发生关系密切,但其具体调控机制不详。本文着重就SPEM的发生、发展过程及与胃癌发病之间关系的研究现状做一综述,为胃癌发病机制的研究提供新思路,为胃癌早期防治提供新理论。
The early diagnosis and treatment of gastric cancer are essential for the prognosis of patients, and they can be realized by exploring the mechanism of precancerous lesions. Spasmolytic polypeptide expressing metaplasia (SPEM) is an important precancerous lesion of gastric cancer, which is closely related to the occurrence of gastric cancer. However, the specific regulatory mechanism remains unclear. This article focuses on the pathogenesis and development of SPEM as well as its relationship with gastric cancer, which may provide new ideas for the pathogenesis, early prevention and treatment of gastric cancer.