Parkinson's disease (PD) is a neurodegenerative disorder characterized with progressive loss of dopaminergic neurons (DA) in the substantia nigra pars compacta (SNpc), accompanied with accumulation of Lewy bodies and proliferation of neuroglial cell. Current studies on the correlation between lipid metabolism and PD suggest that different kinds of lipids play an important role in the progression of PD. However, as it was influenced by a variety of factors (age, gender or etiology) in clinical, it is difficult to obtain a specific link between lipids and development of PD. This article aims to review the progress of lipids in PD, deepen the understanding of pathology and pathogenesis of PD, and provide new potential targets for the treatment of PD.