National Natural Science Foundation of China（No.82003725）
帕金森病（Parkinson's disease, PD）是一种神经退行性疾病，其主要病理学特征为黑质纹状体通路多巴胺能神经元进行性丢失，同时伴随路易小体形成和胶质细胞增生。目前报道的脂质代谢与PD发病相关性的研究表明不同类型的脂质在PD进展中发挥重要作用。但因临床患者受多种因素的影响（年龄、性别或病因），故难以获得脂质与PD发生发展之间的明确联系。本文旨在综述脂质在PD中的研究进展，深化对PD病理和发病机制的认识，以期为治疗PD提供新的潜在靶点和研究方向。
Parkinson's disease (PD) is a neurodegenerative disorder characterized with progressive loss of dopaminergic neurons (DA) in the substantia nigra pars compacta (SNpc), accompanied with accumulation of Lewy bodies and proliferation of neuroglial cell. Current studies on the correlation between lipid metabolism and PD suggest that different kinds of lipids play an important role in the progression of PD. However, as it was influenced by a variety of factors (age, gender or etiology) in clinical, it is difficult to obtain a specific link between lipids and development of PD. This article aims to review the progress of lipids in PD, deepen the understanding of pathology and pathogenesis of PD, and provide new potential targets for the treatment of PD.