Objective：To investigate the perioperative difference between obtaining the great saphenous vein by "no-touch" or No-touch method and obtaining the great saphenous vein by conventional technique during off-pump coronary artery bypass grafting, whether patients have different effects. Method：A total of 106 cases of off-pump coronary artery bypass grafting were included in this study. There were 55 patients in the No-touch group and 51 patients in the conventional group, while the No-touch group harvested the saphenous vein graft with the No-touch technique, and the conventional group used the conventional incision. Observation indicators included total operation time, intraoperative bridge vessel flow, intensive care unit stay time, drainage volume, postoperative cardiac troponin, creatine kinase isoenzyme, myoglobin, and leg healing. Result：There was one death in the conventional group among the 106 patients who received off-pump coronary artery bypass grafting. There were no significant differences between two group in operation duration, intraoperative venous graft blood flow, major adverse cardiovascular events, postoperative 24-hour drainage volume, postoperative myocardial markers, and poor leg healing（P<0.05）. Conclusion：These findings show that the No-touch and the conventional harvesting technique make no difference in the perioperative period of coronary artery bypass grafting.