Objective To explore the efficacy of multimodal of patient controlled intravenous analgesia (PCIA) combined with quadratus lumborum block (QLB) for postoperative analgesia in cesarean delivery under general anesthesia. Methods Ninety parturients, aged 21~40, ASA Ⅰ or Ⅱ, scheduled for caesarean delivery under general anesthesia were randomly divided into two groups with 45 in each: Group B-Q (butorphanol tartrateScombined with QLB group), Group Q-Q (oxycodone combined with QLB group). The VAS scores at rest and movement, Ramsay sedation scores and BCS scores were recorded at 2, 4, 8, 12, 24 h after operation. Time of leaving bed, the number of successfully delivered doses, the total analgesic consumption during PCIA, the requirement for rescue analgesia and the satisfaction score of analgesia were recorded within 24 h after surgery. The adverse reactions such as nausea and vomiting, somnolence, pruritus during analgesia were also recorded. Result Compared with group B-Q, the VAS scores during motion were significantly lower in group Q-Q at 8h, 12h after operation (P＜0.05). The BCS scores were significantly higher in group Q-Q at 8h, 12h, 24h (P＜0.05). The time in bed, the number of successfully delivered doses and the total analgesic consumption during PCIA were significantly decreased in group Q-Q (P＜0.05). Compared with group B-Q, the satisfaction score of analgesia were significantly higher in group Q-Q (P＜0.05). Conclusion oxycodone PCIA combined with QLB can be used safely and effectively for postoperative analgesia in cesarean delivery under general anesthesia, enhance recovery after cesarean delivery, and improve the satisfaction of parturients.