微小RNA在缺血性脑卒中的研究进展
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江苏大学附属人民医院

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江苏省科技发展计划(MS2021083);镇江市重点研发计划(SH2019081)


Research advances of MicroRNA in ischemic stroke
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1.Affiliated People'2.'3.s Hospital of Jiangsu University

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Jiangsu Science and Technology Development Plan(MS2021083);Zhenjiang City key research and development plan(SH2019081)

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    摘要:

    微小RNA(microRNA,miRNA)是一种特殊RNA,其不直接翻译成蛋白质,在基因转录后水平发挥作用,是最先被研究的非编码RNA之一。MiRNA在哺乳动物神经系统中表达丰富,在神经退行性损伤、脑卒中、脑外伤等疾病中均参与调控。近年来的研究发现miRNA与缺血性脑卒中关系尤为密切。文章归纳总结了miRNA在缺血性脑卒中作为诊断和判断预后的生物标记物以及作为治疗靶点的脑保护机制最新进展,为以miRNA为核心的核酸治疗应用临床提供借鉴与依据。

    Abstract:

    MicroRNA(MiRNA), a class of specialized RNA that does not translate directly into proteins and function at the post-transcriptional level of genes, is the first non-coding RNA to be studied. MiRNA is richly expressed in the mammalian nervous system, and is involved in the regulation of neurodegenerative injury, stroke, brain injury and other diseases. Recent studies have found that miRNA is particularly closely associated with ischemic stroke. This paper summarized the latest progress of miRNA in the diagnosis and prognosis of ischemic stroke as biomarkers and brain protection mechanisms as therapeutic targets, providing reference and basis for the clinical application of nucleic acid therapy with miRNA as the core.

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  • 收稿日期:2022-06-15
  • 最后修改日期:2022-09-05
  • 录用日期:2023-04-17
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