The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)
肠道微生物群的组成或功能失调与多种疾病相关。粪便微生物群移植（fecal microbiota transplantation, FMT）是通过将供体微生物群移植至受体肠道内，重建受体肠道微生物网络，进而治疗与肠道微生物群失调相关慢性疾病的一种微生态疗法，其适应症已从肠道疾病扩展到肠道外疾病。尽管FMT可治愈90%的复发性艰难梭菌感染，然而FMT在其他复杂疾病中的疗效不尽相同，且在治疗相同疾病的患者时存在显著的个体差异。这表明存在多种因素影响FMT治疗疾病的疗效，本文将从供体和受体两方面因素对FMT中供体微生物群植入和临床疗效的影响予以综述。
Gut dysbiosis has been identified as a potential factor that may drive a variety of diseases. Fecal microbiota transplantation (FMT) is a microecological therapy which delivers fecal microbiota of screened healthy donor into the recipient intestine. By restructuring the recipient gut microbiota with donor fecal samples, FMT has been used to treat a number of gastrointestinal and non-gastrointestinal disorders. Although FMT could cure 90% of recurrent C. difficile infections, the efficacy of FMT in other diseases is variable. These suggests that there are multiple factors influence the efficacy of FMT. This article will discuss the impact of both donor and recipient factors on donor microbiota engraftment and clinical efficacy in FMT.