202例外周T细胞淋巴瘤临床特征分析及预后新模型建立
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南京医科大学第一附属医院,江苏省人民医院

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Analysis of clinical characteristics and establishment of a new prognostic model in 202 cases with peripheral T-cell lymphomas
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    摘要:

    【摘要】目的:外周T细胞淋巴瘤(Peripheral T-cell lymphomas, PTCL)是一组异质性的非霍奇金淋巴瘤,本研究旨在探索PTCL患者的临床特征,寻找影响无进展生存期(progression-free survival, PFS)和总生存期(overall survival, OS)的新指标,建立新的预后模型。方法:回顾性分析2009年7月至2021年9月于南京医科大学第一附属医院(江苏省人民医院)就诊的202例PTCL患者的临床资料,采用Kaplan-Meier法、单因素和多因素Cox回归分析等进行生存分析和预后因素评估。结果:所有PTCL患者中位PFS与OS分别为11个月和43个月。血红蛋白(Hemoglobin, Hb)正常患者的PFS(44个月 vs. 9个月,P<0.001)和OS(83个月 vs. 24个月,P=0.002)均优于Hb水平低于正常的患者。ECOG评分>1(P=0.009)和Hb水平低于正常(P=0.007)是PFS的独立危险因素,年龄>60岁(P=0.015)和ECOG评分>1(P=0.002)是OS的独立危险因素。Hb水平联合国际预后指数(International Prognostic Index, IPI)和T细胞淋巴瘤预后指数(Prognostic Index for T-cell lymphoma, PIT)评分提高了预测PFS的准确性。结论:Hb水平可以作为评估PTCL患者预后的指标,Hb水平联合IPI和PIT可以提高预测PTCL患者预后的准确性。

    Abstract:

    【Abstract】Objective: Peripheral T-cell lymphomas (PTCL) is a heterogeneous group of non-Hodgkin’s lymphomas. This study aimed to analyze the clinical features of PTCLs patients, exploring new factors which affected progression-free survival (PFS) and overall survival (OS) to establish new prognostic models. Methods: The clinical data of 202 patients with PTCLs from the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital) from July 2009 to September 2021 were retrospectively analyzed. We also performed Kaplan-Meier method, univariate and multivariate Cox regression analysis for survival analysis and prognostic factors evaluation. Results: The PFS and OS of all PTCL patients were 11 months and 43 months respectively. Patients with lower level of hemoglobin (Hb) showed worse PFS (9 months vs 44 months, P<0.001) and OS (24 months vs 83 months, P=0.002) than patients with normal level of Hb. ECOG scores >1 (P=0.009) and lower Hb level (P=0.007) were independent risk factors for PFS. Age >60 years (P=0.015) and ECOG score >1 (P=0.002) were independent risk factors for OS. International Prognostic Index (IPI) and Prognostic Index for T-cell lymphoma (PIT) respectively combined with Hb level improved the accuracy of predicting PFS of PTCL. Conclusion: The level of Hb may be a good candidate for predicting prognosis of PTCL. Hb level combined with IPI and PIT can improve the ability to predict prognosis of PTCL patients.

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  • 收稿日期:2022-11-01
  • 最后修改日期:2022-11-16
  • 录用日期:2023-03-02
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