Abstract:Objective: To explore the clinical characteristics of pregnant women with scarred uterus who have occurred uterine rupture induced by intraamniotic injection of ethacridine lactate through analyzing their clinical data. Methods: Retrospective analyze the clinical data of pregnant women with uterine rupture induced by intraamniotic injection of ethacridine lactate and delivered in Women’s Hospital of Nanjing Medical University from December 2015 to December 2021. The relevant literature collected in CNKI, Wanfang database, VIP, Sinomed database from January 1, 2000 to January 1, 2022 were summarized and analyzed. Results: During the past six years, there were 7 cases of pregnant women with uterine rupture after induction of labor by intraamniotic injection of ethacridine lactate in our hospital. All of them were pregnant women with scar uterus after cesarean section. There are 6 cases whose rupture was located at the original scar site, and 1 case located at the lower uterine segment near the inner cervical orifice. Three cases were found after delivery and 4 cases before delivery. The main clinical symptoms were abdominal pain and hemorrhagic shock. Among the retrieved 12 cases of uterine rupture, two cases were found after abortion and 10 cases were found before abortion. The main clinical symptoms were severe abdominal pain and hemorrhagic shock. Conclusion: There is a high risk of uterine rupture for pregnant women with scarred uterus induced by intraamniotic injection of ethacridine lactate. When clinical workers are dealing with such pregnant women, choice of labor induction method should be carefully and individually selected, close attention should be paid to the abdominal pain and vital signs during induction of labor, and laparotomy and imaging are feasible when necessary.