间充质干细胞来源外泌体治疗心肌梗死的研究进展
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国家自然科学基金(81971624,81901759)


Research progress of exosomes derived from mesenchymal stem cells in myocardial infarction
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    摘要:

    大量研究表明间充质干细胞(mesenchymal stem cell,MSC)主要通过旁分泌作用抑制细胞凋亡、抑制心肌纤维化、促进血管生成、抑制免疫反应来修复心肌损伤,外泌体在其中起主要作用。外泌体是细胞分泌的天然的纳米载体,内含细胞特异性蛋白、核酸和脂质。与脂质体载体相比,还具有低免疫原性、无细胞毒性及能够穿透生物屏障等优点。目前已有多种靶向心脏的工程外泌体在动物心肌梗死模型中取得很好的疗效。本文就MSC及MSC来源外泌体促进心肌梗死后受损心肌修复的机制及研究进展作一综述。

    Abstract:

    There is mounting evidence that mesenchymal stem cell(MSC) help repair damage myocardial tissues primarily by means of secreting paracrine factors to inhibit cell apoptosis,inhibit myocardial fibrosis,promote angiogenesis and inhibit immune response. Recent studies have confirmed that these effects may be mainly mediated by exosomes. Exosomes are natural nano carriers secreted by cells,and contain cell-specific nucleic acids,proteins and lipids. Compared to liposome carriers,exosomes are low toxicity,less immunogenic,and can penetrate biological barriers. At present,many kinds of engineered exosomes targeting the heart have achieved good curative effects in animal models of myocardial infarction. This article reviews the mechanism research progress of MSC and exosomes derived from MSC in promoting the repair of damaged myocardium after myocardial infarction.

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蒋日月,邓 倾,周 青.间充质干细胞来源外泌体治疗心肌梗死的研究进展[J].南京医科大学学报(自然科学版),2022,42(4):588-594

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  • 收稿日期:2021-11-28
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  • 在线发布日期: 2022-04-25
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