文章摘要
刘扣英,王 彤,张希龙,殷凯生,陈俊娣.缬沙坦对哮喘大鼠气道炎症及气道反应性的影响[J].南京医科大学学报,2006,(11):1021~1024
缬沙坦对哮喘大鼠气道炎症及气道反应性的影响
Effects of valsartan on airway inflammation and responsiveness in asthmatic rats
投稿时间:2006-06-19  
DOI:10.7655
中文关键词: 缬沙坦  哮喘  气道反应性  炎症
英文关键词: valsartan  asthma  airway responseness  inflammation
基金项目:江苏省高校自然科学研究基金资助(04KJB320089)
作者单位
刘扣英 南京医科大学第一附属医院呼吸科江苏 南京 210029 
王 彤  
张希龙  
殷凯生  
陈俊娣  
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中文摘要:
      目的:研究血管紧张素Ⅱ受体拮抗剂缬沙坦对哮喘大鼠气道炎症及气道反应性的干预作用。方法: 50只Wistar大鼠随机分成5组,每组10只:A组(正常对照组)、B组(哮喘组)、C组[15 mg/(kg·d)缬沙坦]、D组[30 mg/(kg·d)缬沙坦]和E组[50 mg/(kg·d)缬沙坦]。应用动物肺功能仪测定大鼠气道反应性,支气管肺泡灌洗液测定细胞总数及嗜酸性粒细胞( eosinophil,EOS)计数。结果:①与A组比,B组肺泡灌洗液中细胞总数和EOS计数增高(P < 0.05,P < 0.01),与B组比,缬沙坦干预后的C组、D组和E组肺泡灌洗液中细胞总数和EOS计数均减少(P < 0.05 ~ 0.01);与C组比,D组肺泡灌洗液中细胞总数和EOS计数均减少(P均 < 0.05)。②当氯化乙酰胆碱(ACH)以较低(10 ~20 μg/ml)浓度激发时,各组大鼠气道阻力(Re)比较差异无统计学意义(P均 > 0.05);Re在ACH(40~320 μg/ml)浓度时,哮喘组的Re较高,与对照组、A组、B组和C组比较差异有统计学意义(P均 < 0.05,320 μg/ml ACH时P < 0.01)。结论:缬沙坦可能是通过抑制AT1受体抑制哮喘气道炎症和降低气道反应性。
英文摘要:
      Objective:To investigate the effects of AngII antagonist valsartan on airway inflammation and airway hyperresponsiveness(AHR) in asthmatic rats. Methods: Fifty Wistar rats were divided into 5 groups, group A(normal control group), group B(asthma group), group C [treated with valsartan, 15mg/(kg·d)], group D[treated with valsartan, 30 mg/(kg·d)],and group E [treated with valsartan, 50 mg/(kg·d)], with 10 rats in each group. Pulmonary function tests were performed to evaluate the airway responsiveness, and bronchial alveolar lavage fluid(BALF) was used to analyze the total cell and eosinophil(EOS) counts. Results: Compared with group A , group B had an increased count of total cell and EOS in BALF(P < 0.05,P < 0.01) . Compared with group B, group C, D, E showed a decreased count of total cell and EOS in BALF(P < 0.05-0.01). Compared with group C, group D had a significantly decreased count of total cell and EOS(P < 0.01) in BALF. After stimulation of methicholine with accelerated concentrations(40,80,160 μg/ml), the mean expiratory resistance(Re) of group B was higher than that of group A, C, D, E(P < 0.05). When the concentration of methicholine was 320 μg/ml, the asthmatic group showed a significant difference. Conclusion: Valsartan may inhibit airway inflammation and reduce airway responsiveness by suppressing AT1 receptors.
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