文章摘要
卢辉和,管耘园,刘亚军,盛臻强,王 毅.缬沙坦对兔经皮动脉成形术后血管内膜增生及PCNA表达的影响[J].南京医科大学学报,2006,(12):1200~1202
缬沙坦对兔经皮动脉成形术后血管内膜增生及PCNA表达的影响
Effects of valsartan on neointimal proliferation and expression of PCNA after balloon angioplasty in rabbits
投稿时间:2006-04-09  
DOI:10.7655
中文关键词: 血管紧张素Ⅱ-Ⅰ受体拮抗剂  缬沙坦  血管成形术  再狭窄  PCNA
英文关键词: angiotensin Ⅱtype 1 receptor antagonists  valsartan  balloon angioplasty  restenosis  PCNA
基金项目:
作者单位
卢辉和 南通大学第二附属医院心内科江苏 南通 226001 
管耘园  
刘亚军  
盛臻强  
王 毅  
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中文摘要:
      目的:观察血管紧张素Ⅱ-1(ATⅡ-1)受体拮抗剂缬沙坦对兔动脉成形术后血管内膜增生及血管平滑肌细胞PCNA表达的影响,探讨AT-Ⅰ受体拮抗剂治疗血管再狭窄的机制和作用。方法:雄性新西兰白兔24只,随机分成3组:对照组始终以普通饲料喂养12周,不加任何处理;模型组和缬沙坦组予高胆固醇喂养, 4周后行腹主动脉内膜剥脱,继续高胆固醇饮食4周后行球囊成形术,模型组继续普通饲料饲养,而缬沙坦组给普通饲料 + 缬沙坦10 mg/(kg·d)喂养4周。12周末取腹主动脉行病理形态学观察及PCNA免疫组织化学分析。结果:缬沙坦组较模型组模型组内膜厚度减少56.58%,内膜面积减少66.81%。免疫组织化学分析显示,缬沙坦组与模型组相比PCNA表达显著减少(P < 0.01)。结论: 缬沙坦可以显著减轻兔腹主动脉成形术后内膜增生,其机制可能与抑制内膜损伤后血管平滑肌细胞PCNA水平,从而抑制血管平滑肌细胞的增生有关。
英文摘要:
      Objective: To investigate the effects of valsartan(angiotensin Ⅱtype 1 receptor antagonists) on neointimal proliferation and expression of PCNA after balloon angioplasty in rabbits. Methods:Twenty-four male New Zealand white rabbits were randomly divided into three groups: control group(fed up with common diet), model group and valsartan group(fed up with hypercholesterolemic diet for 4 weeks, then undergoing balloon angioplasty). Four weeks after balloon angioplasty operation, model group was fed up with common diet, whereas valsartan group was fed up with the mixture of valsartan[10 mg/(kg ·d)] and common diet. The rabbits were killed at the end of the 12th week, The abdominal aorta was examined with pathologic and morphologic analysis, and the expression of PCNA was analyzed with immunohistochemical method. Results:Compared with model group, the neointimal thickness and area were decreased by 56.58% and 66.81% in valsartan group. The expression of PCNA was significantly lower in valsartan group(P < 0.01). Conclusion:Valsartan could inhibit neointimal proliferation of rabbits’ abdominal aorta after balloon injury, the mechanism might be correlated with the decreased level of PCNA in vascular smooth muscle cells, and the inhibited proliferation of vascular smooth muscle cells.
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