文章摘要
顾晓峰,黎逢峰,范卫民,刘 军,许 凯.液氮冷冻并血管破坏建立犬股骨头缺血坏死塌陷模型的实验研究[J].南京医科大学学报,2006,(12):1224~1226
液氮冷冻并血管破坏建立犬股骨头缺血坏死塌陷模型的实验研究
The experimental research of setting up the subsiding model of avascular necrosis of femoral head
投稿时间:2006-05-30  
DOI:10.7655
中文关键词: 液氮冷冻  股骨头缺血坏死  动物模型
英文关键词: froze by liquid nitrogen  avascular necrosis of femoral head  animal model
基金项目:
作者单位
顾晓峰 南京医科大学附属无锡一院骨科江苏 无锡 214002 
黎逢峰 南京医科大学第二附属医院骨科江苏 南京 210011 
范卫民 南京医科大学第一附属医院骨科江苏 南京 210029 
刘 军 南京医科大学第二附属医院骨科江苏 南京 210011 
许 凯 华中科技大学同济医学院附属同济医院骨科湖北 武汉 430003 
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中文摘要:
      目的:探索建立股骨头缺血性坏死塌陷模型的方法。方法:用液氮将股骨头冷冻坏死,并破坏股骨头基底部的血管和软组织,术后定期摄X线片,并取股骨头内部组织切片了解股骨头坏死及修复情况。结果:术后第3、7和11周组织切片均见股骨头骨坏死,骨修复不明显, 术后X线片可见股骨头骨坏死,但第11周才见股骨头明显塌陷。结论:液氮冷冻并血管破坏可建立典型的犬股骨头缺血性坏死塌陷模型。
英文摘要:
      Objective:To research the method of establishing subsiding model of avascular necrosis of femoral head. Methods: Femoral heads were frozen by liquid nitrogen, and the blood vessel and parenchyma of fundus were destroyed. X-ray and histology examination were made periodically after operation to evaluate osteo necrosis and the subsequent repair. Results:Necrosis of the femoral head was confirmed by histology in the thirty week、the seventh week and the eleventh week after operation, but repairing is not obvious. Radiographic evidence and gross observation showed Necrosis of the femoral head, but obvious subsiding appeared in the eleventh week. Conclusion:The typical animal subsiding model of avascular necrosis of the femoral head can be established with blood vessel destroy and liquid nitrogen freezing.
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