文章摘要
吴 珺,鲁一兵,缪 珩,许 旌.选择性血管紧张素Ⅱ受体拮抗剂对糖尿病大鼠血管单核细胞趋化蛋白-1表达的影响[J].南京医科大学学报,2007,(2):145~149
选择性血管紧张素Ⅱ受体拮抗剂对糖尿病大鼠血管单核细胞趋化蛋白-1表达的影响
Effect of Valsartan on the expression of monocyte chemoattractant protein-1 in the arteria of diabetic rats
投稿时间:2006-07-28  
DOI:10.7655
中文关键词: 糖尿病  大鼠  单核细胞趋化蛋白-1  缬沙坦
英文关键词: diabetes  rat  monocyte chemoattractant protein-1  Valsartan
基金项目:江苏省卫生厅科研基金项目(H200320)
作者单位
吴 珺 南京医科大学第二附属医院内分泌科江苏 南京 210011 
鲁一兵  
缪 珩  
许 旌  
摘要点击次数: 883
全文下载次数: 101
中文摘要:
      目的:研究选择性血管紧张素Ⅱ受体拮抗剂(缬沙坦)对STZ诱导的糖尿病大鼠血管组织单核细胞趋化蛋白-1(MCP-1)表达的影响。方法: 将SD大鼠随机分成三组:正常对照组(NC组)、糖尿病组(DM组)、糖尿病 + 缬沙坦干预组(DV组)。观察各组大鼠的血糖、体重、Hb1Ac,于8周时用RT-PCR和Western blot的方法检测链脲佐菌素(STZ)诱导的糖尿病大鼠血管组织中MCP-1的表达的变化。结果:DM和DV组大鼠体重较NC组明显降低(均P < 0.01),DM和DV组间糖化血红蛋白(HbA1c)及血糖无显著性差异(P > 0.05); DM和DV组大鼠血管组织中MCP-1 mRNA的表达明显高于NC组(均P < 0.01),而DV组明显低于DM组(P < 0.01); DM和DV组大鼠血管组织中MCP-1 蛋白的表达明显高于NC组(均P < 0.01),而DV组明显低于DM组(P < 0.01)。结论:糖尿病SD大鼠血管组织单核细胞趋化蛋白-1(MCP-1)表达明显增加,缬沙坦通过降低血管组织炎症因子MCP-1表达,对糖尿病大血管并发症起防治作用。
英文摘要:
      Objective:To investigate the effects of Valsartan on the expression of monocyte chemoattractant protein-1(MCP-1) in the arteria of STZ-induced diabetic rats. Methods:SD rats were randomly divided into NC group,DM group and DV group. Blood glucose(BG), body weight(BW), and HbA1c were observed. the expression of MCP-1 in the arteria of diabetic rats was detected by RT-PCR and Western blot at the 8 th week. Results:The BW of diabetic rats in DM and DV groups decreased significantly compared with NC group(P < 0.01), but no notable difference was found in HbA1c and BG between DM and DV group(P > 0.05). The expression of MCP-1 mRNA in DM and DV groups was much higher than that in NC group(P < 0.01), but it was much lower in DV group than that in DM group(P < 0.01). The expression of MCP-1 protein in DM and DV groups was much higher than that in NC group(P < 0.01), and it was much lower in DV group than that in DM group(P < 0.01). Conclusion:The expression of MCP-1 is much higher in the arteria of diabetic rats. Valsartan could obviously reduce the expression of MCP-1 in the arteria of diabetic rats and ameliorate the inflammation in the arteria.
查看全文   查看/发表评论  下载PDF阅读器
关闭