Objective：To investigate the growth inhibition of Oxaliplatin（L-OHP） or Cisplatin（CDDP） in vitro and Livin gene expression induced by the two platinum compounds on human gastric cancer cell line（BGC-823）. Methods：The proliferation inhibition ratio was evaluated by MTT in the time of 24, 48 and 72 hours. Different inhibiting concentrations（IC10, IC30 and IC50） of the two platinum compounds were added into the medium of BGC-823 cells. The expression of Livin gene was detected by RT-PCR, and the protein of Livin was assessed by Western-blot. Results：The proliferation of BGC-823 was inhibited in a dose-and time-dependent manner after the treatment of CDDP or L-OHP, especially the latter was dose-dependent significantly than the former. The expression of Livin, which was down-regulated by the two platinum compounds in the earlier period, was up-regulated after 72 hours with CDDP ｏｔｈｅｒ ｔｈａｎ L-OHP. Conclusion：L-OHP, which can more significantly inhibit the proliferation of BGC-823 in a dose-dependent manner than CDDP, is a potent inhibitor of Livin. The different influences on the expression of Livin will contribute to the investigation of regulation and function on Livin.