文章摘要
方海飞,沈美萍,徐银峰.甲状腺乳头状癌TGF-β1、CD31表达与肿瘤转移的关系[J].南京医科大学学报,2007,(5):472~475
甲状腺乳头状癌TGF-β1、CD31表达与肿瘤转移的关系
Study on the expressions of TGF-β1, CD31 in human papillary thyroid cancer and the correlation with lymph node metastasis
投稿时间:2006-11-20  
DOI:10.7655
中文关键词: 甲状腺乳头状癌  TGF-β1  CD31  肿瘤转移
英文关键词: papillary thyroid carcinoma  TGF-β1  CD31  metastasis
基金项目:浙江省教育厅科研基金资助项目(20061127)
作者单位
方海飞 南京医科大学第一附属医院普外科江苏 南京 210029 
沈美萍 南京医科大学第一附属医院普外科江苏 南京 210029 
徐银峰 浙江海洋学院医学院组胚教研究浙江 舟山 316004 
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中文摘要:
      目的: 研究甲状腺乳头状癌组织中TGF-β1和CD31的表达水平与甲状腺癌转移的关系。方法:分别应用原位杂交法和EnVisionTM免疫组织化学法检测55例甲状腺乳头状癌和10例癌周组织TGF-β1mRNA、TGF-β1蛋白和CD31蛋白的表达;并计数CD31标记的肿瘤组织微血管密度。结果:甲状腺乳头状癌组织TGF-β1mRNA阳性为表达率为80.00%,甲状腺乳头状癌组织中TGF-β1阳性表达率为76.37%,均高于癌周组织,差异有统计学意义(P < 0.01);微血管密度(MVD)与TGF-β1的表达之间存在正相关关系。结论:TGF-β1促进甲状腺癌肿瘤微血管形成,在肿瘤转移中起重要的作用。
英文摘要:
      Objective:To study the expressions of TGF-β1, CD31 in papillary thyroid cancer tissues and the correlation with the lymph node metastasis. Methods:The expression of TGF-β1mRNA was detected by in situ hybridization, and the expressions of TGF- β1, CD31 were detected by EnVisionTM immunohistochemistry method in 55 tomour tissues and 10 normal tissues; the expression of CD31 was used as the mark of the vascular endothelial cell for detecting the tumor microvascular density(MVD). Results:The positive expression rate of TGF-β1mRNA in papillary thyroid cancer was 80.00%. The positive expression rate of TGF-β1 in papillary thyroid cancer was 76.37%. The expression levels of TGF-β1 mRNA and TGF- β1 in papillary thyroid cancer tissue were higher than those in normal throid tissue(P < 0.01). There was positive correlation between MVD and TGF-β1. Conclusion:TGF-β1 could could promote the microvascular formation in papillary thyroid cancer tissues and play an important role in the lymph nodes metastasis.
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