文章摘要
丁国芳,方海飞,徐银峰,郁迪.TGF-β1mRNA在胃癌中表达及其与淋巴转移、生存率的相关性研究[J].南京医科大学学报,2007,(6):573~575578
TGF-β1mRNA在胃癌中表达及其与淋巴转移、生存率的相关性研究
Study of the correlation between the expression of TGF-β1mRNA and lymphatic metastases,survival rate with gastric cancer
投稿时间:2006-09-09  
DOI:10.7655
中文关键词: TGF-β1mRNA  肿瘤淋巴转移  生存率  胃癌
英文关键词: TGF-β1mRNA  lymph metastases  survival rate  gastric cancer
基金项目: 浙江省舟山市科研基金资助项目(2003461)
作者单位
丁国芳 浙江海洋学院医学院人体解剖与组织胚胎学教研究浙江 舟山 316004 
方海飞  
徐银峰  
郁迪  
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中文摘要:
      目的:研究转化生长因子-β1mRNA(TGF-β1mRNA)在胃癌组织中的表达及其与淋巴结转移、术后生存率的关系。方法:用原位杂交法检测66例胃癌切除标本中癌组织和10例癌周组织TGF-β1mRNA表达;结合临床资料分析TGF-β1mRNA与胃癌患者术后生存率的关系。结果:胃癌患者中66.67%在术后5年内死亡。胃癌中TGF-β1mRNA阳性表达率86.36%。TGF-β1mRNA表达阴性或弱阳性者47.50%术后生存5年以上,52.50%5年内死亡,TGF-β1mRNA表达呈中、强阳性者11.54%术后生存5年以上,88.46%5年内死亡(P < 0.05)。无淋巴结转移者TGF-β1mRNA阳性表达率75.00%,有淋巴结转移者TGF-β1mRNA阳性表达率97.06%(P < 0.05)。TGF-β1mRNA高表达与胃癌的进展呈正相关。结论:TGF-β1可促进胃癌生长,增加胃癌的侵袭能力和淋巴转移。提示对胃癌患者行TGF-β1mRNA检测,可判断胃癌的进展和预后。
英文摘要:
      Objective:To study the correlation between the expression of TGF-β1mRNA in gastric cancer tissues and the tumor lymph node metastasis and survival rate after operation,the expression can be used to estimate progression and prognosis. Methods:Using in situ hybridization method,66 specimens and 10 normal tissue specimens(controls) were tested for the expression of TGF-β1mRNA. The survival rate after operation was investigated also. The correlation between TGF-β1mRNA and survival rate was analyzed. Results:The gastric cancer in 66 specimens died in 5 year was 88.46%(23/26). The positive expression rate of TGF-β1mRNA in gastric cancer was 86.36%(57/66),while it was 10.00%(1/10) in controls,indicating significant difference between them(P < 0.01). The negative and lower positive expression of TGF-β1mRNA in those who died after 5 years was 47.50%(19/40),in those who died in 5 year was 52.50%(21/40),indicating significant difference between them(P < 0.05). The middle and strong positive expression of TGF-β1mRNA in those who died after 5 years was 11.54%(3/26), in those who died in 5 year was 88.46%(23/26). The positive expression of TGF-β1mRNA in those who have no tumor lymph node metastasis was 75.00%(24/32),while it was 97.06%(33/34) in those who have tumor lymph node metastasis,indicating significant difference between them(P < 0.05). There was positive correlation between the higher expression of TGF-β1mRNA and the worse prognosis and rapid progression of gastric cancer. Conclusion:TGF-β1 can stimulate gastric cancer grow and become more aggressive and the tumor lymph metastasis. The detection of TGF-β1mRNA can be used to estimate gastric cancer patients,progression and prognosis.
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