文章摘要
黄亚辉,谈珊柏,梁萍,刘存明.预注雷米芬太尼缓解丙泊酚乳剂注射痛的临床观察[J].南京医科大学学报,2007,(6):606~608
预注雷米芬太尼缓解丙泊酚乳剂注射痛的临床观察
Remifentanil pretreatment to alleviate pain on propofol injection
投稿时间:2006-12-19  
DOI:10.7655
中文关键词: 丙泊酚  注射痛  雷米芬太尼  利多卡因
英文关键词: propofol  injection pain  remifentanil  lidocaine
基金项目:
作者单位
黄亚辉 南京医科大学第一附属医院麻醉科江苏 南京 210029 
谈珊柏  
梁萍  
刘存明  
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中文摘要:
      目的:观察预先注射雷米芬太尼对丙泊酚乳剂注射痛的缓解作用。方法:采用随机对照双盲法,选取150例接受全麻的择期外科手术患者,随机分3组:雷米芬太尼50 ?滋g组(Ⅰ组)、利多卡因40 mg组(Ⅱ组)、生理盐水组(Ⅲ组)。各组患者预先静脉注入试验药物,30 s后注入异丙酚(2 mg/kg)。观察询问各组患者的疼痛分级及不适反应,并记录用药前后的血压、心率变化。结果:Ⅰ组、Ⅱ组较Ⅲ组疼痛程度及注射痛发生率明显降低(分别为16%、24%、86%,P < 0.05),各组用药前后血压及心率无显著变化(P > 0.05)。结论:预注雷米芬太尼能显著缓解丙泊酚注射痛。
英文摘要:
      Objective:To evaluate the effect of remifentanil pretreatment on propofol injection pain. Methods:A double blind and randomized study of 150 adults undergoing general anesthesia(GA) for elective surgery was conducted. All patients were randomly assigned to one of the three groups: groupⅠ(n = 50) received 10 ml of remifentanil 50 ?滋g pretreatment, groupⅡ(n = 50) received 2% lidocaine 40 mg pretreatment, and group Ⅲ received normal saline pretreatment followed 30 s later by propofol 2 mg/kg. During induction of GA, the pain response was recorded. Hemodynamic data were also recorded. Results:The incidence and intensity of injection pain was significantly less in the group ⅠandⅡ than those in the group Ⅲ(P < 0.05), and the hemodynamic data were not significantly changed(P > 0.05). Conclusion:Propofol-induced pain can be reduced by remifentanil pretreatment.
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