Objective:To investigate the clinical significance of calcaneal quantitative ultrasound(QUS) for the female with QUS,and to investigate the relationship of QUS with DEXA. Methods:QUS and DEXA were performed in 511 female cases,aged 20-83 years. Results:Broadband ultrasound attenuation(BUA),speed of sound(SOS) and stiffness index(SI) of the female calcaneus were moderately related to bone mineral density(BMD) of Lumbar,Femur Neck,Femur Ward’s,Femur Troch,Total(r = 0.447-0.625);BUA,SOS and SI decreased obviously when the females were over 50 years old;BUA,SOS and SI in the calcaneus of the postmenopausal women were significantly less than those of the premenopausal women and decreased with the increase of the age. Those parameters of the osteoporosis group were obviously lower than those of the control group. Conclusion:Calcaneal QUS can indicate the change of female bone quality with the increase of ages. This is an effective method to diagnose osteoporosis and worth of introducing widely.