文章摘要
周 蓉,崔胜忠,谢桂琴,陈 玲,袁孝如.NMDA受体对纹状体长时程增强和强直刺激后c-fos表达的影响[J].南京医科大学学报,2007,(11):1205~1208
NMDA受体对纹状体长时程增强和强直刺激后c-fos表达的影响
Effects of NMDA receptor on striatal long-term potentiation and c-fos expression induced by high frequency stimulus
投稿时间:2007-05-28  
DOI:10.7655
中文关键词: 长时程增强  NMDA受体  MK-801  c-fos  纹状体
英文关键词: long term potentiation  NMDA receptor  MK-801  c-fos  striatum
基金项目:国家自然科学基金资助(30572173,30370449);江苏省高校自然科学基金资助(06KJB180071);南京医科大学科技发展基金(NY0509)
作者单位
周 蓉 南京医科大学生理学系江苏 南京 210029 
崔胜忠  
谢桂琴  
陈 玲  
袁孝如  
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中文摘要:
      目的:观察NMDA受体对强直刺激后纹状体长时程增强和c-fos 表达的影响。方法:采用纹状体离体脑片细胞外记录电生理技术和免疫组化技术。结果:NMDA受体的拮抗剂MK-801(20 μmol/L)完全抑制了长时程增强的产生以及强直刺激后c-fos的表达。结论:NMDA受体参与了纹状体长时程增强的过程和强直刺激后c-fos的表达。
英文摘要:
       Objective:To investigate the effects of NMDA receptor on the long term potentiation(LTP) and c-fos expression induced by high frequency stimulus. in rat striatum in vitro. Methods:Both extracellular field potential recording and immunochemistry method were used in the study. Results:The results showed that LTP was inhibited by NMDA receptor antagonist MK-801(20 ?滋mol/L) completely, and that activation of c-fos induced by tetanic stimulus in the same slices was inhibited. Conclusion:The present results demonstrated that NMDA receptor was involved in LTP and c-fos expression after tetanic stimulation.
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