文章摘要
孙思鑫,曹晓建,汪 雷,孙 钰,张 洁,刘 波.FTY720与他克莫司对脊髓损伤有显著疗效[J].南京医科大学学报,2008,28(1):20~
FTY720与他克莫司对脊髓损伤有显著疗效
The comparative study of treatment in experimental spinal cord injury by FTY720 with FK506
投稿时间:2007-09-09  
DOI:10.7655
中文关键词: 脊髓损伤  FTY720  FK506
英文关键词: spinal cord injury  FTY720  FK506
基金项目:江苏省自然科学基金资助(BK2005436);省卫生厅“科教兴卫工程”医学重点人才资助(RC2007060)
作者单位
孙思鑫 南京医科大学第一附属医院骨科,江苏 南京 210029 
曹晓建 南京医科大学第一附属医院骨科,江苏 南京 210029 
汪 雷 南京医科大学第一附属医院骨科,江苏 南京 210029 
孙 钰 南京医科大学第一附属医院骨科,江苏 南京 210029 
张 洁 南京医科大学第一附属医院骨科,江苏 南京 210029 
刘 波 南京医科大学第一附属医院骨科,江苏 南京 210029 
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中文摘要:
      目的:探讨FTY720与他克莫司(FK506)对脊髓损伤后神经功能保护作用的差别?方法:雄性SD大鼠48只随机分为4组,FTY720治疗组,FK506治疗组,损伤(不给药)组和正常对照?参照Allen’s 法建立T10 脊髓损伤动物模型,分别予FTY720与FK506治疗?伤后1?3?7?14?21天行BBB评分及斜板试验,伤后3周行体感诱发电位(SEP)检查及T10段脊髓切片HE染色?结果:神经功能BBB评分?斜板最大角度及体感诱发电位检测,FTY720治疗组均优于FK506治疗组,差异有显著性(P < 0.05); HE染色可见损伤组脊髓内大量神经元坏死,用药治疗各组神经元坏死较轻,其中以FTY720组最轻?结论:脊髓损伤后早期应用FTY720与FK506治疗均有显著疗效,两者相比又以FTY720效果更优?
英文摘要:
      Objective:To compare the differences of neuroprotective effect between FTY720 and FK506 on spinal cord injury(SCI). Methods:A total of 48 male rats were divided randomly into 4 groups:①the test group treated with FTY720;②the test group treated with FK506;③the injuried group and ④the control group. While A-C group were enrolled to establish SCI models using Allen method before treated. The neurological function score and immunohistochemical examination were assessed at certain time after injury. Results:The group of FTY720 was better than the group of FK506 in the detection of Inclined Plate Test scores,BBB scales and SEP test. In injury group,a large number of neuronal death could be seen,and pathological changes in treatment group were better than those in injuried group. The pathological changes in the test group treated with FTY720 group was lest. Conclusion:Early using both of FTY720 and FK506 might be capable of treating SCI,and the effect of FTY720 was superior to FK506.
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