文章摘要
徐晓琴,羊海涛,陈国红,丁 萍,胡海洋,李 雷.江苏省未接受治疗的HIV感染者和患者免疫功能状况研究[J].南京医科大学学报,2008,28(1):82~85
江苏省未接受治疗的HIV感染者和患者免疫功能状况研究
Research on immune status of people infected by HIV without clinical therapy and AIDS patients in Jiangsu province
投稿时间:2007-08-09  
DOI:10.7655
中文关键词: 艾滋病病毒感染者  CD3+ CD4+ CD8+ T淋巴细胞  结核感染
英文关键词: HIV infected people  CD4+ CD8+ T-lymphocyte  TB infection
基金项目:江苏省科技厅基金资助(BS2006078)
作者单位
徐晓琴 江苏省疾病预防控制中心,江苏 南京 210009 
羊海涛 江苏省疾病预防控制中心,江苏 南京 210009 
陈国红 江苏省疾病预防控制中心,江苏 南京 210009 
丁 萍 江苏省疾病预防控制中心,江苏 南京 210009 
胡海洋 江苏省疾病预防控制中心,江苏 南京 210009 
李 雷 江苏省疾病预防控制中心,江苏 南京 210009 
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中文摘要:
      目的:了解江苏省HIV感染者T淋巴细胞的变化及合并结核杆菌感染的情况,为抗病毒治疗提供参考依据?方法:应用流式细胞仪?X线拍片机及痰检的方法分析140例正常人?116例HIV感染者的T淋巴细胞亚群及其合并结核的情况?结果:HIV感染者CD4+细胞数低于正常人群(P < 0.001),CD4+/CD8+的比值明显降低(P < 0.001);CD4+细胞 < 200个/?滋l者占37.07%,>200个/?滋l者占62.93%,两组人群的CD8+ T淋巴细胞?Th/Ts有显著性差异;其中77.59%无临床症状,有临床相关症状的占22.41%,两组人群的CD4+细胞数及Th/Ts有显著性差异;共11例合并结核感染?结论:HIV感染机体后,CD4+?CD8+细胞水平的变化与病情发展关系密切,联合检测的判断能力优于单项检测?
英文摘要:
       Objective:To discuss the variety of T-lymphocytes and the combining TB infection of the HIV infected people in Jiangsu province to provide the reference for anti-virus treatment. Methods:The T-lymphocytes subsets from the samples of 140 normal people and 116 HIV infected people were analyzed by flow cytometry. The combining TB infection situation of the HIV infected people were detected by X-ray and sputum examination. Results:The total count of CD4+ T-lymphocytes was lower in HIV infected people than that of normal people(P < 0.001). CD4+/CD8+ ratio of all infected people was obviously lower than that of normal people(P < 0.001). 37.07% infected people had CD4+ T-lymphocytes count lower than 200 ?滋l. The CD8+ T-lymphocytes counts and the Th/Ts of the two groups had significant difference. 90 of the 116(77.59%) HIV infected people didn’t have clinical symptoms and the others appeared related clinical symptoms. The CD4+ T-lymphocyte count and the ratio of the Th/Ts between two groups had significant difference. 11 HIV infected people were also infected by TB. Conclusion:When the object was infected by HIV, the number of CD4+ T-lymphocyte count and CD8+ T-lymphocyte count were firmly correlated with the course of disease. Both CD8+ and CD4+ testing was superior to single testing.
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