文章摘要
肖炜明,施瑞华,丁岩冰,龚卫娟,薛 艳,李 强.胃癌组织EGFR和COX-2的表达与幽门螺杆菌感染关系[J].南京医科大学学报,2008,28(4):449~452
胃癌组织EGFR和COX-2的表达与幽门螺杆菌感染关系
Expression EGFR and COX-2 in human gastric carcinoma and their relationship with H.pylori infection
  
DOI:10.7655
中文关键词: 胃癌  EGFR  COX-2  幽门螺杆菌  相关性
英文关键词: gastric carcinoma  EGFR  COX-2  H. pylori  correlation
基金项目:江苏省卫生厅科研项目(Z2006027)
作者单位
肖炜明 扬州大学附属扬州第一医院消化科江苏 扬州 225001 
施瑞华 南京医科大学第一附属医院消化科江苏 南京 210029 
丁岩冰 扬州大学附属扬州第一医院消化科江苏 扬州 225001 
龚卫娟 扬州大学医学院免疫教研室江苏 扬州 225001 
薛 艳 扬州大学附属扬州第一医院消化科江苏 扬州 225001 
李 强 扬州大学附属扬州第一医院消化科江苏 扬州 225001 
摘要点击次数: 1076
全文下载次数: 152
中文摘要:
      目的:探讨表皮生长因子受体(EGFR)、环氧化酶-2(COX-2)在胃癌组织中的表达及其相关性,并探究它们与幽门螺杆菌(H.pylori)感染的关系。方法:采用免疫组化EnVision两步法检测47例胃癌组织及相应的20例癌旁组织EGFR、COX-2的表达;用快速尿素酶诊断法和13C呼气试验两种方法检测胃癌患者H.pylori感染状况。结果:胃癌组织中EGFR、COX-2的阳性表达率均明显高于癌旁组织(P < 0.01);EGFR、COX-2在胃癌中表达呈正相关(P < 0.05)。有H.pylori感染的胃癌组织中EGFR、COX-2的阳性表达率较未感染的胃癌组织中高(P < 0.01)。结论:EGFR、COX-2在胃癌组织中高表达且有相关性,H.pylori感染可能上调胃癌组织中EGFR、COX-2的表达。
英文摘要:
      Objective:To investigate the expression of EGFR and COX-2 and their correlations in human gastric carcinoma,and analyze their relationship with H.pylori infection. Methods:By Immunochemical EnVision method,the expression of EGFR and COX-2 were detected in 47 cases of gastric cancer and 20 cases of cancer-adjacent tissues. The statuses of H.pylori infection were detected by fast urea enzyme test and 13C breath test. Results:The positive rates of EGFR and COX-2 in gastric carcinoma were significantly higher than those in paraneoplastic tissues(P < 0.01). There were significantly positive correlation between the expression of EGFR,COX-2(P < 0.05),and the expression with H.pylori infection were higher than those without H.pylori infection(P < 0.01). Conclusion:EGFR and COX-2 were overexpressed in gastric carcinoma,and there were positive correlations between them. H.pylori infection could upregulate the expression of EGFR and COX-2 in gastric cancer tissues.
查看全文   查看/发表评论  下载PDF阅读器
关闭