文章摘要
杨 静,束永前.非小细胞肺癌中VEGF-C?PDGF-BB与淋巴管生成和淋巴结转移的关系[J].南京医科大学学报,2008,28(5):580~584653
非小细胞肺癌中VEGF-C?PDGF-BB与淋巴管生成和淋巴结转移的关系
Relationship among VEGF-C,PDGF-BB,lymphangiogenesis and lymph node metastasis in human non-small cell lung cancer
投稿时间:2008-01-22  
DOI:10.7655
中文关键词: 非小细胞肺癌  血管内皮生长因子C  血小板衍生生长因子BB  淋巴管生成
英文关键词: non-small cell lung cancer  vascular endothelial growth factor C  platelet-derived growth factor BB  lymphangiogenesis
基金项目:江苏省卫生厅科学技术发展基金(K200601)
作者单位
杨 静 南京医科大学第一附属医院肿瘤科,江苏 南京 210029 
束永前  
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中文摘要:
      目的:探讨血管内皮生长因子C(VEGF-C)和血小板衍生生长因子BB(PDGF-BB)在非小细胞肺癌(NSCLC)中的表达与淋巴管生成和淋巴结转移的关系?方法:分别应用免疫组化SP法和Envision System法检测40例NSCLC和10例肺良性病变组织中VEGF-C和PDGF-BB的表达;应用淋巴管特异标志Podoplanin检测NSCLC中淋巴管密度(LVD),并做相关统计分析?结果:VEGF-C和PDGF-BB在NSCLC中阳性表达率均显著高于肺良性病变(VEGF-C:62.5% vs 10%,P < 0.05;PDGF-BB:60% vs 10%,P < 0.05)?淋巴结阳性组的VEGF-C阳性表达率显著高于淋巴结阴性组(94.1% vs 39.1%,P < 0.05),但未发现PDGF-BB表达与淋巴结有关(76.5% vs 47.8%,P > 0.05)?NSCLC中淋巴结阳性组的LVD显著高于淋巴结阴性组(16.58 ± 2.38 vs 9.88 ± 1.93,P < 0.05),VEGF-C和PDGF-BB阳性表达组的LVD均显著高于阴性表达组(VEGF-C:14.74 ± 3.62 vs 9.37 ± 1.35,P < 0.05;PDGF-BB:13.84 ± 4.23 vs 11.06 ± 2.90,P < 0.05)?NSCLC中VEGF-C与PDGF-BB的表达具有显著相关性(rs=0.422,P < 0.05)?结论:淋巴管生成是淋巴结转移的一个重要因素;PDGF-BB参与了淋巴管生成,但对于促进淋巴结转移可能不是必要的;VEGF-C通过参与淋巴管生成而促进淋巴结转移,其预测NSCLC发生淋巴结转移可能性的价值优于PDGF-BB;PDGF-BB和VEGF-C在促进淋巴管生成的作用上可能具有相关性?
英文摘要:
      Objective:To explore the relationship among vascular endothelial growth factor C(VEGF-C),platelet-derived growth factor BB(PDGF-BB),lymphangiogenesis and lymph node metastasis in human non-small cell lung cancer(NSCLC). Methods:Forty cases of NSCLC with complete follow-up information and ten cases of lung benign diseases were included. Tumor samples were immunostained for vascular endothelial growth factor-C(VEGF-C),platelet-derived growth factor BB(PDGF-BB) and the lymphatic endothelial markers Podoplanin. Lymphatic vessel density(LVD) was evaluated within NSCLC. Results:Both of the positive rate of VEGF-C and PDGF-BB in the human NSCLC group were significantly higher than that in the lung benign diseases group(VEGF-C:62.5% vs 10%,P < 0.05;PDGF-BB:60% vs 10%,P < 0.05). In NSCLC the positive rate of VEGF-C in the positive lymph node group was significantly higher than that in the negative lymph node group(94.1% vs 39.1%,P < 0.05). However,no significant correlation was found between the expression of PDGF-BB and lymph node status(76.5% vs 47.8%,P > 0.05). In NSCLC the LVD in the positive lymph node group was significantly higher than that in the negative lymph node group(16.58 ± 2.38 vs 9.88 ± 1.93,P < 0.05). LVDs in the positive VEGF-C and PDGF-BB group were significantly higher as compared with the negative expression group(VEGF-C:14.74 ± 3.62 vs 9.37 ± 1.35,P < 0.05;PDGF-BB:13.84 ± 4.23 vs 11.06 ± 2.90,P < 0.05). Furthermore,there was significant correlation between VEGF-C and PDGF-BB in human NSCLC(rs = 0.422,P < 0.05). Conclusion:Lymphangiogenesis is a significant factor for tumor lymphatic metastasis. PDGF-BB may not be necessary for lymphatic metastasis in human NSCLC despite mediating lymphangiogenesis. VEGF-C may accelerate lymphatic metastasis in human NSCLC by inducing lymphangiogenesis,and it may be more valuable than PDGF-BB for forecasting the status of lymphatic metastasis in human NSCLC. There might be similar mechanism between VEGF-C and PDGF-BB on mediating lymphangiogenesis.
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