糖尿病患者尿微量白蛋白与动脉硬化指数之间的关系
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Arterial stiffness index and microalbuminuria in patients with type 2 diabetes
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    目的:探讨糖尿病患者动脉僵硬度与尿中微量白蛋白的关系,并对影响动脉硬化指数(arterial stiffness index,ASI)的因素进行初步探讨-方法:对入选的135例糖尿病患者,应用CardioVisionMS-2000动脉硬度测量仪测定ASI,反映外周血管弹性-并对所有入选对象进行晨尿尿白蛋白/肌酐比值(albumin/creatinine ratio,ACR) 测定,据结果分为增高-正常2组,应用统计学方法进行组间差异比较分析-并对影响ASI的因素进行探讨-结果:尿白蛋白/肌酐比值增高患者ASI明显高于正常组(P < 0.01),2组之间年龄-收缩压(SBP)-脉压(PP)-高密度脂蛋白胆固醇(HDL-C)-肾小球滤过率(GFR)-糖化血红蛋白(HbA1C),以及糖尿病病程亦有明显差异(P < 0.05).单因素相关分析显示,年龄-SBP-PP-低密度脂蛋白胆固醇(LDL-C)-GFR-HbA1C-尿白蛋白/肌酐比值-糖尿病病程与ASI明显相关(P < 0.05)-多因素逐步线性回归分析确定PP-HbA1C-尿白蛋白/肌酐比值以及糖尿病病程为ASI的独立影响因素-结论:糖尿病患者中,尿白蛋白/肌酐比值与应用ASI反应的血管硬化情况明显相关-

    Abstract:

    Objective:To investigate the relationship between microalbuminuria and arterial stiffness index in diabetes patients. Methods:A total of 135 patients with diabetes were studied. Arterial Stiffness Index(ASI) which can reflect large arterial compliance was measured by CardioVisionMS-2000 arterial stiffness detector. Albumin/creatinine ratio(ACR) was determined. Results:ASI was higher in high ACR group than in normal ACR group. There were significant differences in age,SBP,PP,HDL-C,GFR,HbA1C,duration of diabetes between two groups(P < 0.05). There was a positive correlation between age,SBP,PP,LDL-C,ACR,HbA1C,duration of diabetes and ASI showed by single factor correlation analysis methods(P < 0.05) However there was a negative correlation between GFR and ASI(P < 0.05). PP,ACR,HbA1C,duration of diabetes were independent risk factors of ASI showed by multiple linear stepwise regression analysis method. Conclusion:The artery compliance as measured by ASI is increased in patients with type 2 diabetes and raised ACR.

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高振才,嵇小兵,张 胜,杨志健.糖尿病患者尿微量白蛋白与动脉硬化指数之间的关系[J].南京医科大学学报(自然科学版),2008,28(6):771-774

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  • 收稿日期:2007-12-12
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