文章摘要
廖培元,吴升华.过敏性紫癜患儿血液脂氧素A4的变化及其临床意义[J].南京医科大学学报,2008,28(7):918~920929
过敏性紫癜患儿血液脂氧素A4的变化及其临床意义
Significance of detecting blood lipoxin A4 in children with Henoch-Schonlein purpura
投稿时间:2008-03-07  
DOI:10.7655
中文关键词: 过敏性紫癜  儿童  脂氧素  白介素  C反应蛋白
英文关键词: Henoch-Schonlein purpura  children  lipoxin  interleukin  C-reactive protein
基金项目:江苏省医学重点人才基金项目(2002-45)
作者单位
廖培元 南京医科大学第一附属医院儿科,江苏 南京 210029 
吴升华  
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中文摘要:
      目的:检测过敏性紫癜患儿在不同发病阶段的血清脂氧素A4(LXA4)的变化,并观察与白介素(IL)-5?IL-6?IL-8和C反应蛋白(CRP)的变化的关系,以探讨LXA4?IL-5?IL-6?IL-8和CRP在过敏性紫癜发病机制中的作用?方法:采集27例过敏性紫癜患儿急性期和恢复早期血液,以及26例正常儿童血液,应用酶联免疫吸附试验(ELISA)检测血清中LXA4?IL-5?IL-6?IL-8和CRP含量?结果:过敏性紫癜患儿的急性期和恢复早期血液LXA4?IL-5?IL-6?IL-8和CRP含量明显高于正常组的含量(P < 0.01);恢复早期患儿LXA4含量明显高于急性期(P < 0.01)?急性期血液IL-5?IL-6?IL-8和CRP含量明显高于恢复早期血液含量(P < 0.01)?LXA4与IL-5?IL-8呈正相关(P < 0.05);LXA4与IL-6?CRP无显著相关性(P > 0.05)?IL-5?IL-6?IL-8和CRP水平各组之间存在正相关性(P < 0.01)?11例重型患儿的急性期?恢复早期LXA4均低于16例轻型患儿(P < 0.05)?结论:过敏性紫癜患儿的急性期血液LXA4?IL-5?IL-6?IL-8和CRP含量升高;恢复早期IL-5?IL-6? IL-8和CRP含量有所下降,而LXA4含量更高;提示IL-5?IL-6?IL-8可能参与过敏性紫癜的病变,而LXA4可能有抗炎作用?重型患儿的LXA4低于轻型患儿,提示体内抗炎物质LXA4不足可能与病情加重有关?
英文摘要:
      Objective:To investigate the serum levels of lipoxin A4(LXA4) in children with Henoch-Schonlein purpura(HSP) in different phase, and explore the correlation of LXA4 with interleukin(IL)-5,IL-6,IL-8 and CRP in the pathogenesis of HSP. Methods:The blood levels of LXA4,IL-5,IL-6,IL-8 and CRP in 26 normal children and 27 children with HSP in acute phase and earlier recovery phase were detected by ELISA,respectively. Results:The blood levels of LXA4,IL-5,IL-6,IL-8 and CRP in children with HSP in acute and earlier recovery phase were significantly higher than those in normal group(P < 0.01),and the blood level of LXA4 in children with HSP in earlier recovery phase was significantly higher than that in the acute phase(P < 0.01). However,the blood levels of IL-5,IL-6,IL-8 and CRP in children with HSP in acute phase were significantly higher than those in earlier recovery phase(P < 0.01). There were positive correlations between LXA4 and IL-5 or IL-8. Meanwhile,there were no positive correlations between LXA4 and IL-6,LXA4 and CRP. There were positive correlations among IL-5,IL-6,IL-8 and CRP. The LXA4 levels of severe patients in acute and earlier recovery phase were lower than that in mild cases. Conclusion:These data suggest that IL-5,IL-6 and IL-8 may play an injurious role, and LXA4 may play a protective role in the pathogenesis of HSP. The insufficiency of LXA4,an anti-inflammatory mediator in human body,may be a reason for the patients with HSP whose illness become more serious.
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