文章摘要
蒋 雯,王美林,张治中,陈小军,朱 慧,钱年风,傅士龙,张正东,韩素萍.XRCC1基因多态性与宫颈癌危险性的研究[J].南京医科大学学报,2009,29(1):1~6
XRCC1基因多态性与宫颈癌危险性的研究
The relationship between XRCC1 polymorphisms and the risk of cervical cancer in Jiangsu population
投稿时间:2008-09-23  
DOI:10.7655
中文关键词: XRCC1基因  宫颈癌  基因多态性  分子流行病学
英文关键词: XRCC1 gene  cervical cancer  polymorphism  molecular epidemiology
基金项目:国家自然科学基金资助(30872084);江苏省省属高校自然科学重大基础研究项目(08KJA330001);教育部生殖医学重点实验室开放基金
作者单位
蒋 雯 南京医科大学第一附属医院妇产科,江苏 南京 210029 
王美林 南京医科大学公共卫生学院,江苏 南京 210029 
张治中 南京医科大学公共卫生学院,江苏 南京 210029 
陈小军 南京医科大学公共卫生学院,江苏 南京 210029 
朱 慧 南京医科大学公共卫生学院,江苏 南京 210029 
钱年风 南京医科大学公共卫生学院,江苏 南京 210029 
傅士龙 南京医科大学第一附属医院妇产科,江苏 南京 210029 
张正东 南京医科大学公共卫生学院,江苏 南京 210029 
韩素萍 南京医科大学第一附属医院妇产科,江苏 南京 210029 
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中文摘要:
      目的:探讨XRCC1基因多态性与江苏人群宫颈癌易感性之间的关系?方法:采用基于医院的分子流行病学病例对照研究方法,选取436例经组织病理学确诊为宫颈癌的新发患者作为病例组和503例年龄(± 5岁)?性别相匹配的非肿瘤者作为对照组;采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法对XRCC1启动子区-77T > C和外显子10区的Arg399Glu基因多态性进行基因分型,比较不同基因型携带者患宫颈癌的危险性;通过分层分析探讨初潮年龄?患者年龄及产次对罹患宫颈癌的影响?结果:与XRCC1-77TT相比,-77TC/CC基因型可减少罹患宫颈癌的危险性(OR=0.64,95%CI=0.48~0.86)?携带3~4个危险等位基因者比携带1~2个等位基因者患宫颈癌的危险性更大(OR=1.44,95%CI=1.01~2.04)?分层分析结果显示,年龄较大和产次较多且携带3~4个危险等位基因者罹患宫颈癌的危险性分别增加1.64倍(95%CI=1.02~2.64) 和1.66倍(95%CI=1.01~2.72)?本研究未发现XRCC1Arg399Glu多态性与宫颈癌之间存在显著性相关?结论:XRCC1基因启动子-77T > C多态性显著降低江苏地区汉族人群罹患宫颈癌的危险性?
英文摘要:
       Objective:To explore the association of XRCC1 gene single nucleotide polymorphisms and the risk of cervical cancer. Methods:In a hospital-based case-control study of 436 patients with newly diagnosed cervical carcinoma and 503 cancer-free controls frequency-matched by age(± 5 years), we genotyped the -77T>C and Arg399Glu polymorphisms of XRCC1 gene by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method. We further analyzed the interaction of age, menarche age, and parity. Results:We found that the -77T>C variant genotypes were associated with significantly decreased risk of cervical cancer adjusted odds ratio(OR) = 0.64; 95% confidence interval(CI)=0.48~0.86, compared with the wild-type homozygote. Moreover, individuals with 3~4 risk alleles increased the risk of cervical cancer accompanied with older age( > 50 years)(OR=1.64, 95%CI=1.02~2.64) and parity(OR=1.66,95%CI=1.01~2.72). By contrast, no significant association was observed between the Arg399Gln polymorphism and cervical cancer risk. Conclusion:Our finding indicated that the XRCC1-77 CC/CT genotype was significantly associated with a decreased risk of cervical cancer in Jiangsu population.
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