文章摘要
王爱萍,刘 超,蒋克春,饶亚平,王 伟.关于2型糖尿病患者合并恶性肿瘤临床特点的调查[J].南京医科大学学报,2009,29(1):102~105
关于2型糖尿病患者合并恶性肿瘤临床特点的调查
The investigation on the clinical characteristics of type 2 diabetes mellitus with malignant tumor
投稿时间:2008-09-05  
DOI:10.7655
中文关键词: 2型糖尿病  恶性肿瘤  二甲双胍
英文关键词: type 2 diabetes mellitus  malignant tumor  metformin
基金项目:
作者单位
王爱萍 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
刘 超 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
蒋克春 解放军第454医院内分泌科,江苏 南京 210002 
饶亚平 解放军第454医院内分泌科,江苏 南京 210002 
王 伟 解放军第454医院内分泌科,江苏 南京 210002 
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中文摘要:
      目的:探讨2型糖尿病患者并发恶性肿瘤的临床规律,为糖尿病患者预防恶性肿瘤的发生提供帮助?方法:调查2000年~2005年资料相对完整的所有含有2型糖尿病的死亡患者,再找出糖尿病至少半年后,合并有恶性肿瘤的患者,从年龄?性别和各系统分布等角度来分析肿瘤分布规律(包括患病率)?结果:2型糖尿病患者201例,女性75例?男性126例,其中恶性肿瘤患者57例,非肿瘤组144例?40~55岁组糖尿病患者肿瘤患病率低?二甲双胍使用率高;肿瘤大多好发于男性;以消化道肿瘤患病率最高,其后依次为血液系统肿瘤?肺部肿瘤和泌尿系统肿瘤;各系统中的肿瘤又有不同的特点,包括糖尿病至肿瘤的病程,以胰腺癌最短,仅在3年左右,肠癌和肺癌较长,在11年左右,而其他肿瘤居中?结论:2型糖尿病患者发生恶性肿瘤的危险性与年龄和性别的相关性更强;糖尿病至肿瘤病程的长短以及各类型肿瘤的特点(包括患病率高低),决定了临床不同时期的筛查重点;二甲双胍可能会有效降低恶性肿瘤的患病率;但肿瘤并不能使糖尿病患者的死亡年龄提前这一点值得思考?
英文摘要:
      Objective:To investigate the clinical characteristics of malignant tumor with type 2 diabetes mellitus. Methods:We assembled a cohort of 201 dead patients from 2000 to 2005 who were diagnosed type 2 diabetes mellitus,and identified those who developed cancer at least six months after meeting criteria for diabetes. We analysed the distribution of malignant tumor in different systems and in various ages. Results:Of 201 diabetic subjects(75 female,126 male), 57 patients were diagnosed carcinoma. The group of 40~55 years were less likely to have cancer,and much more to use metformin. A larger proportion of those who developed malignant tumors were males. The probability of cancer in digestive system,blood system,respiratory system and urinary system went down sequencely. Cancer were identified in different time after the date diabetes criteria were met in different systems:only about 3 years of pancreatic cancer, about 11 years of colonic cancer and lung cancer, and the middle of other cancers. Conclusion:The incidence of cancer among persons with diabetes was significantly correlated with age and sex. The distributing characteristics of carcinoma associated with diabetes were different in different systems. Metformin may be associated with a decrease in risk of cancer of diabetes patients. But the dead ages of diabetes subjects with and without cancer were not different which need further researches.
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