文章摘要
史 彧,褚莉莉,张兰芳,赵德育.哮喘患儿CD4+CD25+调节性T细胞及FOXP3的表达[J].南京医科大学学报,2009,29(1):117~119
哮喘患儿CD4+CD25+调节性T细胞及FOXP3的表达
Role of CD4+CD25+ regulation cells and expressing of FOXP3 in the pathogenesis of children with asthma
  
DOI:10.7655
中文关键词: CD4+CD25+调节性T细胞  FOXP3  哮喘  流式细胞术
英文关键词: CD4+CD25+ T regulate cells  FOXP3  asthma  flow cytometry
基金项目:南京医科大学科技发展基金面上项目(07NMUM079)
作者单位
史 彧 南京医科大学附属南京儿童医院呼吸科,江苏 南京 210008 
褚莉莉  
张兰芳  
赵德育  
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中文摘要:
      目的:研究CD4+CD25+调节性T细胞在哮喘儿童外周血中的比例改变,并探讨其临床意义?方法:采用细胞内染色的流式细胞术检测急性发作期哮喘患儿外周血CD4+CD25+ Treg及其调控基因FOXP3的表达,并与健康对照组进行比较?结果:急性发作期哮喘患儿外周血CD4和CD25双阳性细胞所占比例与健康对照组无明显差异(P > 0.05),而CD4+CD25+FOXP3 调节性T细胞在外周血中的比例明显低于健康对照组(P < 0.01)?结论:哮喘患儿外周血CD4+CD25+FOXP3调节性T细胞在外周血中的比例明显减少,可能与哮喘的发病机制有关?
英文摘要:
      Objective:To investigate the change of CD4+CD25+ T regulation cells in peripheral blood in children with asthma. Methods:CD4+CD25+FOXP3 T regulate cells in children with asthma were measured by intracellular 3-colour flow cytometry in peripheral blood cells in children with asthma. Results:There were similar frequencies of CD4+CD25+ T cells in peripheral blood of asthma children and health control. However, the quantity of CD4+CD25+FOXP3 T regulate cells was decreased significantly in peripheral blood of patients with asthma in comparison with that of normal controls(P < 0.01). Conclusion:The proportion of CD4+CD25+FOXP3 T regulate cells decreased in children with asthma, which might contribute to the pathological process of such disease.
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