ITGA6?CTHRC1在食管鳞癌中的表达及临床意义
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

"兴卫工程"重点医学人才项目[苏卫科教(2008)2号]


ITGA6?CTHRC1 expression in esophageal squamous cell cancer and their clinical significance
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:研究食管鳞癌中ITGA6(integrin α6)-CTHRC1(collagen triple helix repeat containing 1)基因的表达,并探讨其与食管鳞癌临床病理参数之间的关系-方法:应用免疫组化S-P法分析46例人食管鳞癌组织及10例食管正常组织中ITGA6-CTHRC1蛋白的表达情况-结果:①ITGA6-CTHRC1在食管鳞癌组织中有增强表达,表达率分别为71.7%(33/46)和56.5%(26/46),而在10例正常食管组织中均未见表达-②ITGA6-CTHRC1在淋巴结转移组中的阳性表达率显著高于无淋巴结转移组(P < 0.05)-③ITGA6-CTHRC1表达与年龄-性别-肿瘤大小及病理类型无明显相关性(P > 0.05)-结论:ITGA6-CTHRC1可能与食管鳞癌侵袭-转移相关,有望成为食管鳞癌新的治疗靶点-

    Abstract:

    Objective:To investigate the expression of ITGA6 and CTHRC1 protein in esophageal squamous cell carcinoma and evaluate their relationship with clinicopathological features. Methods:Immunohistochemical SP method was used to detect the expression of ITGA6 and CTHRC1 protein in 46 cases with esophageal squamous cell carcinoma and 10 cases with normal esophagus tissue. Results:①The higher expression of ITGA6 and CTHRC1 was observed in esophageal squamous cell carcinoma,the expression rates were 71.7%(33/46)and 56.5%(26/46),the negative expression was detected in 10 cases with normal esophagus tissue.②There was significantly higher expression in the cases with metastasis than these with non-metastasis(P < 0.05).③The expression of ITGA6 and CTHRC1 was not significantly related with age-sex-size of tumer and pathological type(P > 0.05). Conclusion:ITGA6 and CTHRC1 are involved in the invasion and metastasis of esophageal squamous cell carcinoma and may be new therapy targets.

    参考文献
    相似文献
    引证文献
引用本文

刘 伟,施瑞华,朱 宏,郝 波. ITGA6?CTHRC1在食管鳞癌中的表达及临床意义[J].南京医科大学学报(自然科学版),2009,29(4):508-511

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2008-11-03
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期:
  • 出版日期: