文章摘要
余章斌,韩树萍,郭锡熔.孕早期胎儿颈项透明层增厚对染色体异常产前筛查价值的Meta分析[J].南京医科大学学报,2009,29(4):569~575581
孕早期胎儿颈项透明层增厚对染色体异常产前筛查价值的Meta分析
Meta-analysis of screening for chromosomal abnormalities using elevated nuchal translucency in first trimester
投稿时间:2008-10-20  
DOI:10.7655
中文关键词: 颈项透明层  胎儿  染色体异常  超声心动描记术  超声检查,产前  Meta分析
英文关键词: nuchal translucency  fetus  chromosomal abnormalities  echocardiography  ultrasonography,prenatal  meta-analysis
基金项目:
作者单位
余章斌 南京医科大学附属南京妇幼保健院儿科,江苏 南京 210004 
韩树萍  
郭锡熔  
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中文摘要:
      目的:探讨孕早期胎儿颈部透明层(NT)增厚在产前超声筛查染色体异常(特别是21-三体综合征)中的价值?方法:检索Cochrane图书馆?PubMed?OVID?Springer数据库?中国期刊网和中国生物医学文献数据库(1990年1月至2008年8月)中的中英文文献,按照诊断试验的纳入标准筛选文献,收集所有相关的诊断试验文献,应用Meta-DiSc 1.4软件对符合条件的研究结果进行Meta分析?结果:共纳入文献14篇,检查胎儿共计162 992人?11篇文献对孕早期胎儿NT≥第95百分位对染色体异常的诊断价值进行了分析,汇总灵敏度?特异性和曲线下面积(AUC)分别为78.8%?92.1%和0.891;12篇文献对孕早期胎儿NT≥第95百分位对21-三体综合征的诊断价值进行了分析,汇总灵敏度?特异性和AUC分别为81.3%?92.6%和0.883?结论:孕早期NT增厚对染色体异常(特别是21-三体综合征)产前诊断的敏感性?特异性和诊断的准确性均较高,可用于孕早期染色体异常的产前筛查?
英文摘要:
      Objective:To evaluate the value of elevated nuchal translucency(NT) as a screening test for chromosomal abnormalities(especially trisomy 21) in a first trimester ultrasound examination. Methods:A search in Cochrane Library, PubMed, OVID, Springer, China National Knowledge Infrastructure(CNKI) and Chinese Bio-medicine Database(CBM) was performed to identify relevant English and Chinese articles between Jan 1990 and August 2008. Criteria for inclusion were established based on validity criteria for diagnostic research. The eligible studies were collected and analyzed using Meta-DiSc 1.4. Results:Fourteen articles were included, with a total of 162992 fetuses. Eleven articles meeting inclusion criteria were analyzed for the value of screening for chromosomal abnormalities by nuchal translucency thickness above the 95th percentile for gestational age. The pooled sensitivity and specificity was 78.8%?92.1% respectively, AUC=0.891. Twelve articles meeting inclusion criteria were analyzed for the value of screening for trisomy 21 by nuchal translucency thickness above the 95th percentile for gestational age. The pooled sensitivity and specificity was 81.3%?92.6% respectively, AUC=0.883. Conclusion:The results suggest that screening for chromosomal abnormalities(especially trisomy 21) by nuchal translucency thickness above the 95th percentile for gestational age has a high sensitivity, specificity, accuracy and is suitable for prenatal screen.
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