文章摘要
王〓芬,王〓丽,殷咏梅.黏附分子CD44s?CD44v6的表达与大肠癌生物学特性的关系[J].南京医科大学学报,2009,29(10):1365~1369
黏附分子CD44s?CD44v6的表达与大肠癌生物学特性的关系
The relationship between CD44s and CD44v6 expression and the biological behavior of human colorectal carcinoma
投稿时间:2009-05-25  
DOI:10.7655
中文关键词: 大肠癌  CD44s  CD44v6  免疫组织化学
英文关键词: colorectal carcinoma  CD44s  CD44v6  immunohistochemistry
基金项目:国家自然科学基金面上项目(30772474);江苏省自然科学基金项目资助(BK2008477)
作者单位
王〓芬 南京医科大学第一附属医院肿瘤科,江苏 南京 210029 
王〓丽 南京医科大学第一附属医院肿瘤科,江苏 南京 210029 
殷咏梅 江苏省肿瘤医院肿瘤科,江苏 南京 210009 
摘要点击次数: 1044
全文下载次数: 151
中文摘要:
      目的:探讨CD44s?CD44v6蛋白在大肠癌组织中的表达及其相关临床意义?方法:应用Envision TM 免疫组化法,回顾性分析57例大肠癌组织中CD44s?CD44v6的表达情况?结果:CD44s?CD44v6在大肠癌中的表达阳性率分别为66.7%?63.2%?CD44s?CD44v6的表达率与肿瘤细胞分化程度?肿瘤分期密切相关(P < 0.05),CD44v6的表达率还与淋巴结转移呈显著相关(P < 0.01)?Kaplan-Meier生存曲线,Log-rank检验单因素生存分析结果显示,CD44s阴性?阳性患者的5年生存率分别为78.95%?55.26%,两者之间差异无显著性(P = 0.062 5);CD44v6阴性?阳性患者的5年生存率分别为80.95%?52.78%,两者之间差异存在显著性(P = 0.014 6)?COX回归多因素生存分析显示,CD44v6对生存有影响(P < 0.05)?结论:CD44s?CD44v6蛋白在大肠癌浸润转移中起重要作用,可以作为一种辅助生物学指标来判断大肠癌浸润转移的潜能,CD44v6可以作为大肠癌独立的预后指标?
英文摘要:
      Objective:To evaluate the expression of CD44s and CD44v6 in colorectal carcinoma and its clinical significance. Methods:The expressions of CD44s and CD44v6 in tumor tissue were detected by immunohistochemically in 57 patients with colorectal carcinoma. Results:The positive rates of CD44s and CD44v6 were 66.7% and 63.2%,respectively. There was significant correlation between CD44s immunoreactivity and Duke's stage,the grade of tumor (P < 0.05,Spearman correlation test). Significant correlation between CD44v6 immunoreactivity and the grade of tumor,Duke’s stage,lymph node metastasis was also noticed (P < 0.05,Spearman correlation test). The 5-year survival rates were 78.95% and 55.26% in CD44s negative cases and CD44s positive ones,respectively. The difference between the two groups was not significant (P > 0.05,Log-rank test). As CD44v6,the 5-year survival rates were 80.95% and 52.78% in CD44v6 negative cases and CD44v6 positive ones,respectively.The difference between the two groups was significant (P < 0.05,Log-rank test). In multivariate analysis using the Cox regression model,CD44v6 expression emerged as an independent prognostic indicator. Conclusion:CD44s and CD44v6 might play important roles in metastasis of colorectal carcinoma,and the expression of CD44v6 might be a new useful independent prognostic marker of colorectal carcinoma.
查看全文   查看/发表评论  下载PDF阅读器
关闭