| 王〓芬,王〓丽,殷咏梅.黏附分子CD44s?CD44v6的表达与大肠癌生物学特性的关系[J].南京医科大学学报,2009,29(10):1365~1369 |
| 黏附分子CD44s?CD44v6的表达与大肠癌生物学特性的关系 |
| The relationship between CD44s and CD44v6 expression and the biological behavior of human colorectal carcinoma |
| 投稿时间：2009-05-25 |
| DOI：10.7655 |
| 中文关键词: 大肠癌 CD44s CD44v6 免疫组织化学 |
| 英文关键词: colorectal carcinoma CD44s CD44v6 immunohistochemistry |
| 基金项目:国家自然科学基金面上项目(30772474);江苏省自然科学基金项目资助(BK2008477) |
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| 中文摘要: |
| 目的:探讨CD44s?CD44v6蛋白在大肠癌组织中的表达及其相关临床意义?方法:应用Envision TM 免疫组化法,回顾性分析57例大肠癌组织中CD44s?CD44v6的表达情况?结果:CD44s?CD44v6在大肠癌中的表达阳性率分别为66.7%?63.2%?CD44s?CD44v6的表达率与肿瘤细胞分化程度?肿瘤分期密切相关(P < 0.05),CD44v6的表达率还与淋巴结转移呈显著相关(P < 0.01)?Kaplan-Meier生存曲线,Log-rank检验单因素生存分析结果显示,CD44s阴性?阳性患者的5年生存率分别为78.95%?55.26%,两者之间差异无显著性(P = 0.062 5);CD44v6阴性?阳性患者的5年生存率分别为80.95%?52.78%,两者之间差异存在显著性(P = 0.014 6)?COX回归多因素生存分析显示,CD44v6对生存有影响(P < 0.05)?结论:CD44s?CD44v6蛋白在大肠癌浸润转移中起重要作用,可以作为一种辅助生物学指标来判断大肠癌浸润转移的潜能,CD44v6可以作为大肠癌独立的预后指标? |
| 英文摘要: |
| Objective:To evaluate the expression of CD44s and CD44v6 in colorectal carcinoma and its clinical significance. Methods:The expressions of CD44s and CD44v6 in tumor tissue were detected by immunohistochemically in 57 patients with colorectal carcinoma. Results:The positive rates of CD44s and CD44v6 were 66.7% and 63.2%,respectively. There was significant correlation between CD44s immunoreactivity and Duke＇s stage,the grade of tumor (P < 0.05,Spearman correlation test). Significant correlation between CD44v6 immunoreactivity and the grade of tumor,Duke’s stage,lymph node metastasis was also noticed (P < 0.05,Spearman correlation test). The 5-year survival rates were 78.95% and 55.26% in CD44s negative cases and CD44s positive ones,respectively. The difference between the two groups was not significant (P > 0.05,Log-rank test). As CD44v6,the 5-year survival rates were 80.95% and 52.78% in CD44v6 negative cases and CD44v6 positive ones,respectively.The difference between the two groups was significant (P < 0.05,Log-rank test). In multivariate analysis using the Cox regression model,CD44v6 expression emerged as an independent prognostic indicator. Conclusion:CD44s and CD44v6 might play important roles in metastasis of colorectal carcinoma,and the expression of CD44v6 might be a new useful independent prognostic marker of colorectal carcinoma. |
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