文章摘要
陈旭东,何〓松,张建兵,陈亚丽.HepPar1等免疫标记在血清甲胎蛋白阴性肝细胞肝癌中的表达及意义[J].南京医科大学学报,2009,29(10):1374~1379
HepPar1等免疫标记在血清甲胎蛋白阴性肝细胞肝癌中的表达及意义
Expression and significance of immune markers in hepatocellular carcinoma with negative serum AFP
投稿时间:2009-05-13  
DOI:10.7655
中文关键词: 肝细胞肝癌  血清甲胎蛋白阴性  免疫组织化学
英文关键词: hepatocellular carcinoma  negative serum AFP  immunohistochemistry
基金项目:南通市社会发展科技计划资助项目(S2006035)
作者单位
陈旭东 南通大学附属肿瘤医院病理科,江苏 南通〓226361 
何〓松  
张建兵  
陈亚丽  
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中文摘要:
      目的:研究HepPar1?甲胎蛋白(AFP)?CD34?CD10?癌胚抗原(CEA)等免疫标记在血清AFP阴性肝细胞肝癌(HCC)中的表达及意义?方法:对100例血清AFP阴性的HCC分别进行HepPar1?AFP?CD34?CD10?CEA免疫组化标记?结果:HepPar1在血清AFP阴性HCC中表达率为86%,其表达与肿瘤的分化程度?结构类型?细胞学亚型及癌周淋巴细胞的多少有关;AFP及CD34在血清AFP阴性HCC中表达率分别为18%和87%,这2个标记均与核分裂的多少?细胞学亚型有关;CD10在血清AFP阴性HCC中表达率为41%,其表达与细胞学亚型及性别有关;CEA在血清AFP阴性HCC中表达率为71%,其表达与各临床病理参数无关?结论:血清AFP阴性HCC有其独特的免疫组化表达?
英文摘要:
      Objective:To investigate the expression and significance of HepPar1,armor embryo protein(AFP),CD34,CD10 and CEA in hepatocellular carcinoma(HCC) with negative serum AFP. Methods:The expression of HepPar1,AFP,CD34,CD10 and CEA was tested by immunohistochemistry in 100 HCC samples with negative serum AFP. Results:In HCC with negative serum AFP,the expression rate of HepPar1 was 86%,and had close correlation with the differentiation,structure type,cytological subtypes and the number of lymphocyte around the tumor;the expression rates of AFP and CD34 were 18% and 87% respectively,and had both close correlation with the number of caryocinesis and cytological subtypes;the expression rate of CD10 was 41%,and had close correlation with the cytological subtypes and gender;the expression rate of CEA was 71%,but had no correlation with the clinical features. Conclusion:Unique immunohistochemical characteristics exist in HCC with negative serum AFP.
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