文章摘要
王〓刚,郑〓静.6-OHDA损毁帕金森大鼠模型和MPTP诱导帕金森小鼠模型的比较[J].南京医科大学学报,2010,(3):383~385419
6-OHDA损毁帕金森大鼠模型和MPTP诱导帕金森小鼠模型的比较
Comparison of two kinds of murine models of Parkinson’s disease:6-OHDA lesioned rats and MPTP induced mice
  
DOI:10.7655
中文关键词: 帕金森病  模型  比较  6-羟基多巴胺  1-甲基-4-苯基-1,2,3,6-四氢吡啶
英文关键词: Parkinson’s disease  models  comparison  6-OHDA  MPTP
基金项目:上海市教育委员会重点学科建设项目(JS001),上海中医药大学校内基金项目(X182)
作者单位
王〓刚 陕西中医学院中西医临床医学系,陕西 咸阳〓712046 
郑〓静 上海中医药大学基础医学院生物化学系,上海〓201203 
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中文摘要:
      帕金森病动物模型是研究帕金森病病因?病机?病理?症状体征?神经保护?药物治疗的必备工具?在众多帕金森病动物模型中目前应用最广泛的是6-OHDA损毁帕金森大鼠模型和MPTP诱导帕金森小鼠模型?为了明确各自特点,作者将两者制备原理?制作方式?检测实验?稳定性?难易度等考虑因素进行对比及评价,以期在帕金森病研究中更好选择和充分利用?
英文摘要:
      Objective:Parkinson’s disease (PD) animal model is an indispensable tool for exploring the etiology,pathogenesis,pathology,symptoms,signs,neuroprotect and drug therapy. Among so many animal models of PD,the most widely used currently are 6-hydroxydopamine (6-OHDA) lesioned rat model and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model. In order to clarify their own characteristics,it is compared and evaluated the preparation principles,production styles,measurement experiments,difficulties,stabilities and other consideration factors of the two kinds of animal models of PD in this article,with a view to make better choices and take full advantages of that in the research of PD.
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